Layer 5 Pyramidal Neuron (Shai et al., 2015)

This work contains a NEURON model for a layer 5 pyramidal neuron (based on Hay et al., 2011) with distributed groups of synapses across the basal and tuft dendrites. The results of that simulation are used to fit a phenomenological model, which is also included in this file.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Neocortex L5/6 pyramidal GLU cell

Transmitters: Glutamate

Model Concept(s): Dendritic Action Potentials; Active Dendrites

Simulation Environment: NEURON; MATLAB

References:

Shai AS, Anastassiou CA, Larkum ME, Koch C. (2015). Physiology of layer 5 pyramidal neurons in mouse primary visual cortex: coincidence detection through bursting. PLoS computational biology. 11 [PubMed]