Model of eupnea and sigh generation in respiratory network (Toporikova et al 2015)

Based on recent in vitro data obtained in the mouse embryo, we have built a computational model consisting of two compartments, interconnected through appropriate synapses. One compartment generates sighs and the other produces eupneic bursts. The model reproduces basic features of simultaneous sigh and eupnea generation (two types of bursts differing in terms of shape, amplitude, and frequency of occurrence) and mimics the effect of blocking glycinergic synapses

Model Type: Realistic Network

Currents: I Na,p; I K,leak; I h; I CAN; I Calcium; Ca pump

Model Concept(s): Calcium dynamics

Simulation Environment: Python


Toporikova N, Chevalier M, Thoby-Brisson M. (2015). Sigh and Eupnea Rhythmogenesis Involve Distinct Interconnected Subpopulations: A Combined Computational and Experimental Study eNeuro. 2 [PubMed]

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