The ZIP file contains a Hodgkin-Huxley based circuit model and the simulation environment MadSim used to study the interaction of leak and IMI on the gastric mill network of the crab (Cancer borealis) as represented in (C. Städele, S. Heigele and W. Stein, 2015) MadSim, the simulation environment used for this study, is freeware and included in the package.
Model Type: Realistic Network
Region(s) or Organism(s): Stomatogastric ganglion
Cell Type(s): Stomatogastric Ganglion (STG) Lateral Gastric (LG) cell
Currents: I MI
Transmitters: CabTRP 1a
Model Concept(s): Temporal Pattern Generation; Invertebrate; Neuromodulation
Simulation Environment: MadSim
References:
Stein W, Straub O, Ausborn J, Mader W, Wolf H. (2008). Motor pattern selection by combinatorial code of interneuronal pathways. Journal of computational neuroscience. 25 [PubMed]
Ausborn J, Stein W, Wolf H. (2007). Frequency control of motor patterning by negative sensory feedback. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]
Städele C, Heigele S, Stein W. (2015). Neuromodulation to the Rescue: Compensation of Temperature-Induced Breakdown of Rhythmic Motor Patterns via Extrinsic Neuromodulatory Input. PLoS biology. 13 [PubMed]
Daur N, Diehl F, Mader W, Stein W. (2012). The stomatogastric nervous system as a model for studying sensorimotor interactions in real-time closed-loop conditions. Frontiers in computational neuroscience. 6 [PubMed]