A biophysical model of thalamocortical network switching under propofol (Soplata et al., 2023)

This is a model of the cortex of (Benita et al., 2012), the thalamus of (Soplata et al., 2017), and simple AMPAergic thalamocortical and corticothalamic connections between them, built using the Matlab-based Dynasim simulator. We used this to investigate how slow wave and alpha oscillations interact under propofol anesthesia, including neuromodulatory changes.

Model Type: Realistic Network

Region(s) or Organism(s): Thalamus; Neocortex

Cell Type(s): Hodgkin-Huxley neuron; Thalamus reticular nucleus GABA cell

Currents: Ca pump; I_K,Na; I h; I T low threshold; I Calcium; I Na, leak; I Na,t; I K; I K,leak

Receptors: AMPA; NMDA; GabaA; GabaB; Cholinergic Receptors; Muscarinic

Transmitters: Gaba; Glutamate; Acetylcholine

Model Concept(s): Activity Patterns; Oscillations; Sleep; Synchronization

Simulation Environment: Network

Implementer(s): Soplata, Austin E


Soplata AE et al. (2023). Rapid thalamocortical network switching mediated by cortical synchronization underlies propofol-induced EEG signatures: a biophysical model. Journal of neurophysiology. 130 [PubMed]

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