The model contains three different isoforms of the calcium L- type channels (Cav1.2 α1-subunit, long and short Cav1.3 α1-subunit splice variants) according to the data and the descriptions of Ortner et al., 2017 J Neurosci. Since calcium overload confers the susceptibility of SNc neurons to neurodegeneration. our work described the impact of the those different L- type calcium isoforms in calcium accumulation, action potential firing and burst firing (NMDA-induced) of the SNc neurons.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Basal ganglia
Cell Type(s): Dopaminergic substantia nigra neuron
Currents: Ca pump; I A; I CAN; I Calcium; I Cl, leak; I Sodium; I h; IK Skca; I_KD
Receptors: NMDA
Genes:
Transmitters: Glutamate
Model Concept(s): Action Potentials; Bursting; Calcium dynamics
Simulation Environment: NEURON
Implementer(s): Dougalis, Antonios [antoniosdougalis at hotmail.com]
References:
Ortner NJ et al. (2017). Lower Affinity of Isradipine for L-Type Ca2+ Channels during Substantia Nigra Dopamine Neuron-Like Activity: Implications for Neuroprotection in Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 37 [PubMed]