"Simulations showed that, following parallel fiber stimulation, Purkinje cells almost linearly increased their response with input frequency, but such an increase was inhibited by stellate cells, which leveled the Purkinje cell gain curve to its 4 Hz value. When reciprocal inhibitory connections between stellate cells were activated, the control of stellate cells over Purkinje cell discharge was maintained only at very high frequencies."
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Cerebellum
Cell Type(s): Hodgkin-Huxley neuron
Currents: I K,Ca; I Na, leak; I h
Receptors: AMPA
Genes:
Model Concept(s): Action Potentials; Synaptic Integration
Simulation Environment: NEURON
Implementer(s): Rizza, Martina Francesca; Masoli, Stefano [stefano.masoli at unipv.it]
References:
Rizza MF et al. (2021). Stellate cell computational modeling predicts signal filtering in the molecular layer circuit of cerebellum. Scientific reports. 11 [PubMed]