DLS, but not DMS or lNAcc projecting dopamine neurons in the SNC produce rebound bursting in vivo and in vitro in the absence of GIRK channel activation due to differences in CaV3, SK, Kv4.
Experimental motivation: Replication of rebound bursts in DLS, but not DMS or lNAcc projecting dopamine neurons in the SNC, associated pharmacology
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Basal ganglia; Mouse
Cell Type(s): Dopaminergic substantia nigra neuron
Currents: I A; I K,Ca; I T low threshold; I h
Receptors: AMPA; D2; GabaA; GabaB; NMDA
Genes:
Model Concept(s): Bursting; Rebound firing
Simulation Environment: NEURON
Implementer(s): Knowlton, Christopher [cknow1 at lsuhsc.edu]
References:
Stojanovic S et al. (2025). Rebound bursting selectively enables fast dynamics in dopamine midbrain neurons projecting to the dorso-lateral striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. [PubMed]