An updated stochastic model of cerebellar Long Term Depression (LTD) with improved realism. Dissociation of Raf kinase inhibitor protein (RKIP) from Mitogen-activated protein kinase kinase (MEK) and Raf kinase are added to an earlier published model. Calcium dynamics is updated as a constant-rate influx to more closely match experiment. AMPA receptor interactions are improved by adding phosphorylation and dephosphorylation of AMPA receptors when bound to glutamate receptor interacting protein (GRIP). The model is tuned to reproduce experimental calcium peak vs LTD amplitude curves accurately at 4 different calcium pulse durations.
Model Type: Synapse; Molecular Network
Region(s) or Organism(s): Cerebellum
Cell Type(s): Cerebellum Purkinje GABA cell
Receptors: AMPA
Model Concept(s): Synaptic Plasticity; Long-term Synaptic Plasticity; Signaling pathways
Simulation Environment: STEPS
Implementer(s): Hepburn, Iain [ihepburn at oist.jp]; Jain, Anant [anantdavinci at gmail.com]; Gangal, Himanshu [himanshugangal at gmail.com]
References:
De Schutter E et al. (2017). A model of induction of cerebellar Long-Term Depression including RKIP inactivation of Raf and MEK Frontiers in Molecular Neuroscience.