Calculating the consequences of left-shifted Nav channel activity in sick cells (Joos et al 2018)


Joos B, Barlow BM, Morris CE. (2018). Calculating the Consequences of Left-Shifted Nav Channel Activity in Sick Excitable Cells. Handbook of experimental pharmacology. 246 [PubMed]

See more from authors: Joos B · Barlow BM · Morris CE

References and models cited by this paper

Banderali U, Juranka PF, Clark RB, Giles WR, Morris CE. (2010). Impaired stretch modulation in potentially lethal cardiac sodium channel mutants. Channels (Austin, Tex.). 4 [PubMed]

Barreto E, Cressman JR. (2011). Ion concentration dynamics as a mechanism for neuronal bursting. Journal of biological physics. 37 [PubMed]

Boucher PA, Joós B, Morris CE. (2012). Coupled left-shift of Nav channels: modeling the Na?-loading and dysfunctional excitability of damaged axons. Journal of computational neuroscience. 33 [PubMed]

Choi JS, Waxman SG. (2011). Physiological interactions between Na(v)1.7 and Na(v)1.8 sodium channels: a computer simulation study. Journal of neurophysiology. 106 [PubMed]

Coggan JS, Ocker GK, Sejnowski TJ, Prescott SA. (2011). Explaining pathological changes in axonal excitability through dynamical analysis of conductance-based models. Journal of neural engineering. 8 [PubMed]

Coggan JS, Prescott SA, Bartol TM, Sejnowski TJ. (2010). Imbalance of ionic conductances contributes to diverse symptoms of demyelination. Proceedings of the National Academy of Sciences of the United States of America. 107 [PubMed]

Cressman JR, Ullah G, Ziburkus J, Schiff SJ, Barreto E. (2009). The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states: I. Single neuron dynamics. Journal of computational neuroscience. 26 [PubMed]

Duménieu M, Oulé M, Kreutz MR, Lopez-Rojas J. (2017). The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms. Frontiers in cellular neuroscience. 11 [PubMed]

Finol-Urdaneta RK, McArthur JR, Juranka PF, French RJ, Morris CE. (2010). Modulation of KvAP unitary conductance and gating by 1-alkanols and other surface active agents. Biophysical journal. 98 [PubMed]

HODGKIN AL, HUXLEY AF. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. The Journal of physiology. 117 [PubMed]

Hübel N, Dahlem MA. (2014). Dynamics from seconds to hours in Hodgkin-Huxley model with time-dependent ion concentrations and buffer reservoirs. PLoS computational biology. 10 [PubMed]

Hübel N, Ullah G. (2016). Anions Govern Cell Volume: A Case Study of Relative Astrocytic and Neuronal Swelling in Spreading Depolarization. PloS one. 11 [PubMed]

Jérusalem A, García-Grajales JA, Merchán-Pérez A, Peña JM. (2014). A computational model coupling mechanics and electrophysiology in spinal cord injury. Biomechanics and modeling in mechanobiology. 13 [PubMed]

Kager H, Wadman WJ, Somjen GG. (2000). Simulated seizures and spreading depression in a neuron model incorporating interstitial space and ion concentrations. Journal of neurophysiology. 84 [PubMed]

Kovalsky Y, Amir R, Devor M. (2009). Simulation in sensory neurons reveals a key role for delayed Na+ current in subthreshold oscillations and ectopic discharge: implications for neuropathic pain. Journal of neurophysiology. 102 [PubMed]

Lachance M, Longtin A, Morris CE, Yu N, Joós B. (2014). Stimulation-induced ectopicity and propagation windows in model damaged axons. Journal of computational neuroscience. 37 [PubMed]

Lauger P. (1991). Electrogenic Ion Pumps.

Ma QX, Arneodo A, Ding GH, Argoul F. (2017). Dynamical study of ?a? channel excitability under mechanical stress. Biological cybernetics. 111 [PubMed]

Morris CE, Boucher PA, Joós B. (2012). Left-shifted nav channels in injured bilayer: primary targets for neuroprotective nav antagonists? Frontiers in pharmacology. 3 [PubMed]

Morris CE, Joos B. (2016). Nav Channels in Damaged Membranes. Current topics in membranes. 78 [PubMed]

Morris CE, Juranka PF. (2007). Nav channel mechanosensitivity: activation and inactivation accelerate reversibly with stretch. Biophysical journal. 93 [PubMed]

Morris CE, Juranka PF, Joós B. (2012). Perturbed voltage-gated channel activity in perturbed bilayers: implications for ectopic arrhythmias arising from damaged membrane. Progress in biophysics and molecular biology. 110 [PubMed]

Ng LJ et al. (2017). A Mechanistic End-to-End Concussion Model That Translates Head Kinematics to Neurologic Injury. Frontiers in neurology. 8 [PubMed]

Ochab-Marcinek A, Schmid G, Goychuk I, Hänggi P. (2009). Noise-assisted spike propagation in myelinated neurons. Physical review. E, Statistical, nonlinear, and soft matter physics. 79 [PubMed]

Prescott SA, Sejnowski TJ, De Koninck Y. (2006). Reduction of anion reversal potential subverts the inhibitory control of firing rate in spinal lamina I neurons: towards a biophysical basis for neuropathic pain. Molecular pain. 2 [PubMed]

Rotstein HG, Oppermann T, White JA, Kopell N. (2006). The dynamic structure underlying subthreshold oscillatory activity and the onset of spikes in a model of medial entorhinal cortex stellate cells. Journal of computational neuroscience. 21 [PubMed]

Shcherbatko A, Ono F, Mandel G, Brehm P. (1999). Voltage-dependent sodium channel function is regulated through membrane mechanics. Biophysical journal. 77 [PubMed]

Sheetz MP, Sable JE, Döbereiner HG. (2006). Continuous membrane-cytoskeleton adhesion requires continuous accommodation to lipid and cytoskeleton dynamics. Annual review of biophysics and biomolecular structure. 35 [PubMed]

Sterratt DC, Graham B, Gillies A, Willshaw D. (2011). Principles of Computational Modelling in Neuroscience, Cambridge University Press.

Tabarean IV, Juranka P, Morris CE. (1999). Membrane stretch affects gating modes of a skeletal muscle sodium channel. Biophysical journal. 77 [PubMed]

Volman V, Ng LJ. (2013). Computer modeling of mild axonal injury: implications for axonal signal transmission. Neural computation. 25 [PubMed]

Volman V, Ng LJ. (2014). Primary paranode demyelination modulates slowly developing axonal depolarization in a model of axonal injury. Journal of computational neuroscience. 37 [PubMed]

Volman V, Ng LJ. (2016). Perinodal glial swelling mitigates axonal degradation in a model of axonal injury. Journal of neurophysiology. 115 [PubMed]

Wang JA et al. (2009). Membrane trauma and Na+ leak from Nav1.6 channels. American journal of physiology. Cell physiology. 297 [PubMed]

Yu N, Morris CE, Joós B, Longtin A. (2012). Spontaneous excitation patterns computed for axons with injury-like impairments of sodium channels and Na/K pumps. PLoS computational biology. 8 [PubMed]

Zou S et al. (2013). Force spectroscopy measurements show that cortical neurons exposed to excitotoxic agonists stiffen before showing evidence of bleb damage. PloS one. 8 [PubMed]

References and models that cite this paper

Barlow BM, Joos B, Trinh AK, Longtin A. (2018). Cooling reverses pathological bifurcations to spontaneous firing caused by mild traumatic injury. Chaos (Woodbury, N.Y.). 28 [PubMed]

Barlow BSM, Longtin A, Joós B. (2024). Impact on backpropagation of the spatial heterogeneity of sodium channel kinetics in the axon initial segment. PLoS computational biology. 20 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.