Nodes of Ranvier with left-shifted Nav channels (Boucher et al. 2012)

The two programs CLSRanvier.f and propagation.f simulate the excitability of a myelinated axon with injured nodes of Ranvier. The injury is simulated as the Coupled Left Shift (CLS) of the activation(V) and inactivation(V) (availability) of a fraction of Nav channels.

Model Type: Axon

Cell Type(s): Myelinated neuron; Hodgkin-Huxley neuron

Currents: I Na,t; I K; I K,leak; Na/K pump; I Na, leak

Genes: Nav1.6 SCN8A

Model Concept(s): Action Potential Initiation; Activity Patterns; Pathophysiology; Conduction failure; Sodium pump; Depolarization block; Homeostasis

Simulation Environment: FORTRAN


Boucher PA, Joós B, Morris CE. (2012). Coupled left-shift of Nav channels: modeling the Na?-loading and dysfunctional excitability of damaged axons. Journal of computational neuroscience. 33 [PubMed]

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