Parallel odor processing by mitral and middle tufted cells in the OB (Cavarretta et al 2016, 2018)

"[...] experimental findings suggest that MC and mTC may encode parallel and complementary odor representations. We have analyzed the functional roles of these pathways by using a morphologically and physiologically realistic three-dimensional model to explore the MC and mTC microcircuits in the glomerular layer and deeper plexiform layers. [...]"

Model Type: Realistic Network

Region(s) or Organism(s): Olfactory bulb

Cell Type(s): Olfactory bulb main tufted middle GLU cell; Olfactory bulb main interneuron granule MC GABA cell; Olfactory bulb main interneuron granule TC GABA cell; Olfactory bulb (accessory) mitral cell; Olfactory bulb main tufted cell external; Olfactory bulb short axon cell

Currents: I A; I Na,t; I_Ks; I K

Receptors: AMPA; GabaA; NMDA

Transmitters: Glutamate; Gaba

Model Concept(s): Action Potentials; Action Potential Initiation; Active Dendrites; Long-term Synaptic Plasticity; Synaptic Integration; Synchronization; Pattern Recognition; Spatio-temporal Activity Patterns; Temporal Pattern Generation; Sensory coding; Sensory processing; Olfaction

Simulation Environment: NEURON

Implementer(s): Cavarretta, Francesco [francescocavarretta at hotmail.it]; Hines, Michael [Michael.Hines at Yale.edu]

References:

Cavarretta F et al. (2018). Parallel odor processing by mitral and middle tufted cells in the olfactory bulb. Scientific reports. 8 [PubMed]

Cavarretta F, Marasco A, Hines ML, Shepherd GM, Migliore M. (2016). Glomerular and Mitral-Granule Cell Microcircuits Coordinate Temporal and Spatial Information Processing in the Olfactory Bulb. Frontiers in computational neuroscience. 10 [PubMed]