Hippocampal CA1 pyramidal cell demonstrating dynamic mode switching (Berteau & Bullock 2020)

A simulated proposed single-cell mechanism for CA1’s behavior as an associative mismatch detector. Shifts in spiking mode (accomplished via KCNQ interaction with chloride leak currents) signal matches vs. mismatches.

Model Type: Neuron or other electrically excitable cell; Predictive Coding Network

Region(s) or Organism(s): Hippocampus

Currents: I M; I Cl, leak; I Na, slow inactivation

Receptors: Gaba; Glutamate; Cholinergic Receptors

Transmitters: Glutamate; Gaba; Acetylcholine

Model Concept(s): Activity Patterns; Coincidence Detection; Rate-coding model neurons; Bursting

Simulation Environment: Python

Implementer(s): Berteau, Stefan [berteau at bu.edu]


Berteau S, Bullock D. (2020). Simulations reveal how M-currents and memory-based inputs from CA3 enable single neuron mismatch detection for EC3 inputs to the CA1 subfield of hippocampus Journal of Neurophysiology, accepted.

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