Ahrén B. (2000). Autonomic regulation of islet hormone secretion--implications for health and disease. Diabetologia. 43 [PubMed]
Ahrén B. (2009). Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes. Nature reviews. Drug discovery. 8 [PubMed]
Alousi AA, Jasper JR, Insel PA, Motulsky HJ. (1991). Stoichiometry of receptor-Gs-adenylate cyclase interactions. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 5 [PubMed]
Ashcroft FM, Rorsman P. (2013). K(ATP) channels and islet hormone secretion: new insights and controversies. Nature reviews. Endocrinology. 9 [PubMed]
Azpiazu I, Gautam N. (2004). A fluorescence resonance energy transfer-based sensor indicates that receptor access to a G protein is unrestricted in a living mammalian cell. The Journal of biological chemistry. 279 [PubMed]
Baggio LL, Drucker DJ. (2007). Biology of incretins: GLP-1 and GIP. Gastroenterology. 132 [PubMed]
Barker CJ, Berggren PO. (2013). New horizons in cellular regulation by inositol polyphosphates: insights from the pancreatic ß-cell. Pharmacological reviews. 65 [PubMed]
Baukrowitz T, Fakler B. (2000). K(ATP) channels: linker between phospholipid metabolism and excitability. Biochemical pharmacology. 60 [PubMed]
Benninger RK, Piston DW. (2014). Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics. Trends in endocrinology and metabolism: TEM. 25 [PubMed]
Berridge MJ. (2009). Inositol trisphosphate and calcium signalling mechanisms. Biochimica et biophysica acta. 1793 [PubMed]
Berridge MJ, Bootman MD, Roderick HL. (2003). Calcium signalling: dynamics, homeostasis and remodelling. Nature reviews. Molecular cell biology. 4 [PubMed]
Bertram R, Sherman A. (2004). A calcium-based phantom bursting model for pancreatic islets. Bulletin of mathematical biology. 66 [PubMed]
Bertram R, Sherman A, Satin LS. (2010). Electrical bursting, calcium oscillations, and synchronization of pancreatic islets. Advances in experimental medicine and biology. 654 [PubMed]
Bokoch GM, Bickford K, Bohl BP. (1988). Subcellular localization and quantitation of the major neutrophil pertussis toxin substrate, Gn. The Journal of cell biology. 106 [PubMed]
Brinkerhoff CJ, Traynor JR, Linderman JJ. (2008). Collision coupling, crosstalk, and compartmentalization in G-protein coupled receptor systems: can a single model explain disparate results? Journal of theoretical biology. 255 [PubMed]
Burant CF et al. (2012). TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial. Lancet (London, England). 379 [PubMed]
Béguin P, Nagashima K, Nishimura M, Gonoi T, Seino S. (1999). PKA-mediated phosphorylation of the human K(ATP) channel: separate roles of Kir6.2 and SUR1 subunit phosphorylation. The EMBO journal. 18 [PubMed]
Calanna S et al. (2013). Secretion of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes: systematic review and meta-analysis of clinical studies. Diabetes care. 36 [PubMed]
Cognard E, Dargaville CG, Hay DL, Shepherd PR. (2013). Identification of a pathway by which glucose regulates ß-catenin signalling via the cAMP/protein kinase A pathway in ß-cell models. The Biochemical journal. 449 [PubMed]
Colsoul B, Vennekens R, Nilius B. (2011). Transient receptor potential cation channels in pancreatic ß cells. Reviews of physiology, biochemistry and pharmacology. 161 [PubMed]
Cooper DM, Karpen JW, Fagan KA, Mons NE. (1998). Ca(2+)-sensitive adenylyl cyclases. Advances in second messenger and phosphoprotein research. 32 [PubMed]
Dai XQ et al. (2012). The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function. Diabetologia. 55 [PubMed]
Dean PM. (1973). Ultrastructural morphometry of the pancreatic -cell. Diabetologia. 9 [PubMed]
Defossa E, Wagner M. (2014). Recent developments in the discovery of FFA1 receptor agonists as novel oral treatment for type 2 diabetes mellitus. Bioorganic & medicinal chemistry letters. 24 [PubMed]
Degerman E et al. (2011). From PDE3B to the regulation of energy homeostasis. Current opinion in pharmacology. 11 [PubMed]
Del Guerra S et al. (2005). Functional and molecular defects of pancreatic islets in human type 2 diabetes. Diabetes. 54 [PubMed]
Delmeire D et al. (2003). Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1. Diabetologia. 46 [PubMed]
Dessauer CW, Scully TT, Gilman AG. (1997). Interactions of forskolin and ATP with the cytosolic domains of mammalian adenylyl cyclase. The Journal of biological chemistry. 272 [PubMed]
Doliba NM et al. (2012). Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics. American journal of physiology. Endocrinology and metabolism. 302 [PubMed]
Doliba NM et al. (2004). Restitution of defective glucose-stimulated insulin release of sulfonylurea type 1 receptor knockout mice by acetylcholine. American journal of physiology. Endocrinology and metabolism. 286 [PubMed]
Doliba NM, Qin W, Vinogradov SA, Wilson DF, Matschinsky FM. (2010). Palmitic acid acutely inhibits acetylcholine- but not GLP-1-stimulated insulin secretion in mouse pancreatic islets. American journal of physiology. Endocrinology and metabolism. 299 [PubMed]
Dolz M et al. (2005). Restitution of defective glucose-stimulated insulin secretion in diabetic GK rat by acetylcholine uncovers paradoxical stimulatory effect of beta-cell muscarinic receptor activation on cAMP production. Diabetes. 54 [PubMed]
Dov A, Abramovitch E, Warwar N, Nesher R. (2008). Diminished phosphodiesterase-8B potentiates biphasic insulin response to glucose. Endocrinology. 149 [PubMed]
Dyachok O, Gylfe E. (2004). Ca(2+)-induced Ca(2+) release via inositol 1,4,5-trisphosphate receptors is amplified by protein kinase A and triggers exocytosis in pancreatic beta-cells. The Journal of biological chemistry. 279 [PubMed]
Dyachok O, Isakov Y, Sågetorp J, Tengholm A. (2006). Oscillations of cyclic AMP in hormone-stimulated insulin-secreting beta-cells. Nature. 439 [PubMed]
Dyer JL, Mobasheri H, Lea EJ, Dawson AP, Michelangeli F. (2003). Differential effect of PKA on the Ca2+ release kinetics of the type I and III InsP3 receptors. Biochemical and biophysical research communications. 302 [PubMed]
Ekanger R, Sand TE, Ogreid D, Christoffersen T, Døskeland SO. (1985). The separate estimation of cAMP intracellularly bound to the regulatory subunits of protein kinase I and II in glucagon-stimulated rat hepatocytes. The Journal of biological chemistry. 260 [PubMed]
Fagerholm V, Haaparanta M, Scheinin M. (2011). a2-adrenoceptor regulation of blood glucose homeostasis. Basic & clinical pharmacology & toxicology. 108 [PubMed]
Falkenburger BH, Dickson EJ, Hille B. (2013). Quantitative properties and receptor reserve of the DAG and PKC branch of G(q)-coupled receptor signaling. The Journal of general physiology. 141 [PubMed]
Falkenburger BH, Jensen JB, Hille B. (2010). Kinetics of M1 muscarinic receptor and G protein signaling to phospholipase C in living cells. The Journal of general physiology. 135 [PubMed]
Falkenburger BH, Jensen JB, Hille B. (2010). Kinetics of PIP2 metabolism and KCNQ2/3 channel regulation studied with a voltage-sensitive phosphatase in living cells. The Journal of general physiology. 135 [PubMed]
Fehmann HC, Göke R, Göke B, Arnold R. (1990). Carbachol priming increases glucose- and glucagon-like peptide-1 (7-36)amide-, but not arginine-induced insulin secretion from the isolated perfused rat pancreas. Zeitschrift fur Gastroenterologie. 28 [PubMed]
Felix-Martinez GJ, Azpiroz-Leehan J, Avila-Poroz R, Godinez-Fernandez JR. (2014). Effect of Impared ATP Production and Glucose Sensitivity on Human beta-cell Function: A Simulation Study Revista Mexicana De Ingenieria Biomedica. 35
Ferdaoussi M et al. (2012). G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1. Diabetologia. 55 [PubMed]
Fiume R et al. (2012). Nuclear PLCs affect insulin secretion by targeting PPAR? in pancreatic ß cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26 [PubMed]
Fridlyand LE, Harbeck MC, Roe MW, Philipson LH. (2007). Regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach. American journal of physiology. Cell physiology. 293 [PubMed]
Fridlyand LE, Jacobson DA, Kuznetsov A, Philipson LH. (2009). A model of action potentials and fast Ca2+ dynamics in pancreatic beta-cells. Biophysical journal. 96 [PubMed]
Fridlyand LE, Jacobson DA, Philipson LH. (2013). Ion channels and regulation of insulin secretion in human ß-cells: a computational systems analysis. Islets. 5 [PubMed]
Fridlyand LE, Ma L, Philipson LH. (2005). Adenine nucleotide regulation in pancreatic beta-cells: modeling of ATP/ADP-Ca2+ interactions. American journal of physiology. Endocrinology and metabolism. 289 [PubMed]
Fridlyand LE, Philipson LH. (2010). Glucose sensing in the pancreatic beta cell: a computational systems analysis. Theoretical biology & medical modelling. 7 [PubMed]
Fridlyand LE, Philipson LH. (2011). Coupling of metabolic, second messenger pathways and insulin granule dynamics in pancreatic beta-cells: a computational analysis. Progress in biophysics and molecular biology. 107 [PubMed]
Fridlyand LE, Tamarina N, Philipson LH. (2003). Modeling of Ca2+ flux in pancreatic beta-cells: role of the plasma membrane and intracellular stores. American journal of physiology. Endocrinology and metabolism. 285 [PubMed]
Fridlyand LE, Tamarina N, Philipson LH. (2010). Bursting and calcium oscillations in pancreatic beta-cells: specific pacemakers for specific mechanisms. American journal of physiology. Endocrinology and metabolism. 299 [PubMed]
Fruman DA, Meyers RE, Cantley LC. (1998). Phosphoinositide kinases. Annual review of biochemistry. 67 [PubMed]
Fujiwara K, Maekawa F, Yada T. (2005). Oleic acid interacts with GPR40 to induce Ca2+ signaling in rat islet beta-cells: mediation by PLC and L-type Ca2+ channel and link to insulin release. American journal of physiology. Endocrinology and metabolism. 289 [PubMed]
Gainetdinov RR, Premont RT, Bohn LM, Lefkowitz RJ, Caron MG. (2004). Desensitization of G protein-coupled receptors and neuronal functions. Annual review of neuroscience. 27 [PubMed]
Garcia MC, Hermans MP, Henquin JC. (1988). Glucose-, calcium- and concentration-dependence of acetylcholine stimulation of insulin release and ionic fluxes in mouse islets. The Biochemical journal. 254 [PubMed]
Gault VA, Kerr BD, Harriott P, Flatt PR. (2011). Administration of an acylated GLP-1 and GIP preparation provides added beneficial glucose-lowering and insulinotropic actions over single incretins in mice with Type 2 diabetes and obesity. Clinical science (London, England : 1979). 121 [PubMed]
Gautam D et al. (2006). A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell metabolism. 3 [PubMed]
Gerencser AA. (2015). Bioenergetic Analysis of Single Pancreatic ß-Cells Indicates an Impaired Metabolic Signature in Type 2 Diabetic Subjects. Endocrinology. 156 [PubMed]
Gilon P, Chae HY, Rutter GA, Ravier MA. (2014). Calcium signaling in pancreatic ß-cells in health and in Type 2 diabetes. Cell calcium. 56 [PubMed]
Gilon P, Rorsman P. (2009). NALCN: a regulated leak channel. EMBO reports. 10 [PubMed]
Gonelle-Gispert C, Costa M, Takahashi M, Sadoul K, Halban P. (2002). Phosphorylation of SNAP-25 on serine-187 is induced by secretagogues in insulin-secreting cells, but is not correlated with insulin secretion. The Biochemical journal. 368 [PubMed]
Gresset A, Sondek J, Harden TK. (2012). The phospholipase C isozymes and their regulation. Sub-cellular biochemistry. 58 [PubMed]
Gromada J, Frøkjaer-Jensen J, Dissing S. (1996). Glucose stimulates voltage- and calcium-dependent inositol trisphosphate production and intracellular calcium mobilization in insulin-secreting beta TC3 cells. The Biochemical journal. 314 ( Pt 1) [PubMed]
Gromada J, Holst JJ, Rorsman P. (1998). Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1. Pflugers Archiv : European journal of physiology. 435 [PubMed]
Guettier JM et al. (2009). A chemical-genetic approach to study G protein regulation of beta cell function in vivo. Proceedings of the National Academy of Sciences of the United States of America. 106 [PubMed]
Göpel S, Kanno T, Barg S, Galvanovskis J, Rorsman P. (1999). Voltage-gated and resting membrane currents recorded from B-cells in intact mouse pancreatic islets. The Journal of physiology. 521 Pt 3 [PubMed]
Haga T. (2013). Molecular properties of muscarinic acetylcholine receptors. Proceedings of the Japan Academy. Series B, Physical and biological sciences. 89 [PubMed]
Harden TK, Waldo GL, Hicks SN, Sondek J. (2011). Mechanism of activation and inactivation of Gq/phospholipase C-ß signaling nodes. Chemical reviews. 111 [PubMed]
Hausdorff WP, Caron MG, Lefkowitz RJ. (1990). Turning off the signal: desensitization of beta-adrenergic receptor function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 4 [PubMed]
Heimann E et al. (2010). Expression and regulation of cyclic nucleotide phosphodiesterases in human and rat pancreatic islets. PloS one. 5 [PubMed]
Hein P, Bünemann M. (2009). Coupling mode of receptors and G proteins. Naunyn-Schmiedeberg's archives of pharmacology. 379 [PubMed]
Hein P, Frank M, Hoffmann C, Lohse MJ, Bünemann M. (2005). Dynamics of receptor/G protein coupling in living cells. The EMBO journal. 24 [PubMed]
Heitzler D et al. (2012). Competing G protein-coupled receptor kinases balance G protein and ß-arrestin signaling. Molecular systems biology. 8 [PubMed]
Henquin JC. (2009). Regulation of insulin secretion: a matter of phase control and amplitude modulation. Diabetologia. 52 [PubMed]
Henquin JC, Garcia MC, Bozem M, Hermans MP, Nenquin M. (1988). Muscarinic control of pancreatic B cell function involves sodium-dependent depolarization and calcium influx. Endocrinology. 122 [PubMed]
Hille B, Dickson E, Kruse M, Falkenburger B. (2014). Dynamic metabolic control of an ion channel. Progress in molecular biology and translational science. 123 [PubMed]
Hinke SA et al. (2002). Dipeptidyl peptidase IV-resistant [D-Ala(2)]glucose-dependent insulinotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats. Diabetes. 51 [PubMed]
Hoare SR. (2005). Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors. Drug discovery today. 10 [PubMed]
Hoffmann C et al. (2012). Comparison of the activation kinetics of the M3 acetylcholine receptor and a constitutively active mutant receptor in living cells. Molecular pharmacology. 82 [PubMed]
Holst JJ, Gromada J. (2004). Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans. American journal of physiology. Endocrinology and metabolism. 287 [PubMed]
Holz GG, Kang G, Harbeck M, Roe MW, Chepurny OG. (2006). Cell physiology of cAMP sensor Epac. The Journal of physiology. 577 [PubMed]
Holz GG, Leech CA, Chepurny OG. (2014). New insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout mice. Biochimica et biophysica acta. 1842 [PubMed]
Iancu RV, Jones SW, Harvey RD. (2007). Compartmentation of cAMP signaling in cardiac myocytes: a computational study. Biophysical journal. 92 [PubMed]
Islam MS. (2010). Calcium signaling in the islets. Advances in experimental medicine and biology. 654 [PubMed]
Itoh Y et al. (2003). Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature. 422 [PubMed]
Jacobson DA, Philipson LH. (2007). TRP channels of the pancreatic beta cell. Handbook of experimental pharmacology. [PubMed]
Jain R, Lammert E. (2009). Cell-cell interactions in the endocrine pancreas. Diabetes, obesity & metabolism. 11 Suppl 4 [PubMed]
Jain S et al. (2013). Chronic activation of a designer G(q)-coupled receptor improves ß cell function. The Journal of clinical investigation. 123 [PubMed]
Jakubík J, Janíčková H, Randáková A, El-Fakahany EE, Doležal V. (2011). Subtype differences in pre-coupling of muscarinic acetylcholine receptors. PloS one. 6 [PubMed]
Jia X, Brown JC, Ma P, Pederson RA, McIntosh CH. (1995). Effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-I-(7-36) on insulin secretion. The American journal of physiology. 268 [PubMed]
Jovic A, Wade SM, Neubig RR, Linderman JJ, Takayama S. (2013). Microfluidic interrogation and mathematical modeling of multi-regime calcium signaling dynamics. Integrative biology : quantitative biosciences from nano to macro. 5 [PubMed]
Kaneto H, Matsuoka TA. (2013). Down-regulation of pancreatic transcription factors and incretin receptors in type 2 diabetes. World journal of diabetes. 4 [PubMed]
Kang ZF et al. (2013). Pharmacological reduction of NEFA restores the efficacy of incretin-based therapies through GLP-1 receptor signalling in the beta cell in mouse models of diabetes. Diabetologia. 56 [PubMed]
Kim M, Huang T, Abel T, Blackwell KT. (2010). Temporal sensitivity of protein kinase a activation in late-phase long term potentiation. PLoS computational biology. 6 [PubMed]
Kim MJ et al. (2001). Distributional patterns of phospholipase C isozymes in rat pancreas. Pancreas. 22 [PubMed]
Kimple ME, Neuman JC, Linnemann AK, Casey PJ. (2014). Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes. Experimental & molecular medicine. 46 [PubMed]
Kitaguchi T, Oya M, Wada Y, Tsuboi T, Miyawaki A. (2013). Extracellular calcium influx activates adenylate cyclase 1 and potentiates insulin secretion in MIN6 cells. The Biochemical journal. 450 [PubMed]
Klingmüller U et al. (2006). Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways. Systems biology. 153 [PubMed]
Kong KC et al. (2010). M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1. Proceedings of the National Academy of Sciences of the United States of America. 107 [PubMed]
Kruse AC, Li J, Hu J, Kobilka BK, Wess J. (2014). Novel insights into M3 muscarinic acetylcholine receptor physiology and structure. Journal of molecular neuroscience : MN. 53 [PubMed]
Kruse M, Hammond GR, Hille B. (2012). Regulation of voltage-gated potassium channels by PI(4,5)P2. The Journal of general physiology. 140 [PubMed]
Lamont BJ et al. (2012). Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice. The Journal of clinical investigation. 122 [PubMed]
Landa LR et al. (2005). Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line. The Journal of biological chemistry. 280 [PubMed]
Latour MG et al. (2007). GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo. Diabetes. 56 [PubMed]
Lemon G, Gibson WG, Bennett MR. (2003). Metabotropic receptor activation, desensitization and sequestration-I: modelling calcium and inositol 1,4,5-trisphosphate dynamics following receptor activation. Journal of theoretical biology. 223 [PubMed]
Li N, Lu J, Willars GB. (2012). Allosteric modulation of the activity of the glucagon-like peptide-1 (GLP-1) metabolite GLP-1 9-36 amide at the GLP-1 receptor. PloS one. 7 [PubMed]
Liang T et al. (2014). Phosphatidylinositol 4,5-biphosphate (PIP2) modulates interaction of syntaxin-1A with sulfonylurea receptor 1 to regulate pancreatic ß-cell ATP-sensitive potassium channels. The Journal of biological chemistry. 289 [PubMed]
Light PE, Manning Fox JE, Riedel MJ, Wheeler MB. (2002). Glucagon-like peptide-1 inhibits pancreatic ATP-sensitive potassium channels via a protein kinase A- and ADP-dependent mechanism. Molecular endocrinology (Baltimore, Md.). 16 [PubMed]
Lin CW, Yan F, Shimamura S, Barg S, Shyng SL. (2005). Membrane phosphoinositides control insulin secretion through their effects on ATP-sensitive K+ channel activity. Diabetes. 54 [PubMed]
Litvin TN, Kamenetsky M, Zarifyan A, Buck J, Levin LR. (2003). Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate. The Journal of biological chemistry. 278 [PubMed]
Logothetis DE, Petrou VI, Adney SK, Mahajan R. (2010). Channelopathies linked to plasma membrane phosphoinositides. Pflugers Archiv : European journal of physiology. 460 [PubMed]
Luik RM, Wang B, Prakriya M, Wu MM, Lewis RS. (2008). Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation. Nature. 454 [PubMed]
Mancini AD, Poitout V. (2013). The fatty acid receptor FFA1/GPR40 a decade later: how much do we know? Trends in endocrinology and metabolism: TEM. 24 [PubMed]
McIntosh CH, Widenmaier S, Kim SJ. (2009). Glucose-dependent insulinotropic polypeptide (Gastric Inhibitory Polypeptide; GIP). Vitamins and hormones. 80 [PubMed]
Mears D et al. (2012). The Anx7(+/-) knockout mutation alters electrical and secretory responses to Ca(2+)-mobilizing agents in pancreatic ß-cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 29 [PubMed]
Meloni AR, DeYoung MB, Lowe C, Parkes DG. (2013). GLP-1 receptor activated insulin secretion from pancreatic ß-cells: mechanism and glucose dependence. Diabetes, obesity & metabolism. 15 [PubMed]
Miguel JC, Abdel-Wahab YH, Green BD, Mathias PC, Flatt PR. (2003). Cooperative enhancement of insulinotropic action of GLP-1 by acetylcholine uncovers paradoxical inhibitory effect of beta cell muscarinic receptor activation on adenylate cyclase activity. Biochemical pharmacology. 65 [PubMed]
Milligan G. (1996). The stoichiometry of expression of protein components of the stimulatory adenylyl cyclase cascade and the regulation of information transfer. Cellular signalling. 8 [PubMed]
Mohammad S et al. (2014). A naturally occurring GIP receptor variant undergoes enhanced agonist-induced desensitization, which impairs GIP control of adipose insulin sensitivity. Molecular and cellular biology. 34 [PubMed]
Molina J et al. (2014). Control of insulin secretion by cholinergic signaling in the human pancreatic islet. Diabetes. 63 [PubMed]
Morgan NG, Montague W. (1985). Studies on the mechanism of inhibition of glucose-stimulated insulin secretion by noradrenaline in rat islets of Langerhans. The Biochemical journal. 226 [PubMed]
Morita H, Morioka T, Hashimoto T MH, Tsuriya D, Oki Y. . (2014). Sulfonylurea (SU) and GLP-1-cAMP related agent Diabetes.
Nadkarni P, Chepurny OG, Holz GG. (2014). Regulation of glucose homeostasis by GLP-1. Progress in molecular biology and translational science. 121 [PubMed]
Nagasumi K et al. (2009). Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice. Diabetes. 58 [PubMed]
Nakajima K et al. (2013). Minireview: Novel aspects of M3 muscarinic receptor signaling in pancreatic ß-cells. Molecular endocrinology (Baltimore, Md.). 27 [PubMed]
Nakashima R et al. (2014). Potentiation of insulin secretion and improvement of glucose intolerance by combining a novel G protein-coupled receptor 40 agonist DS-1558 with glucagon-like peptide-1 receptor agonists. European journal of pharmacology. 737 [PubMed]
Nauck MA, Baller B, Meier JJ. (2004). Gastric inhibitory polypeptide and glucagon-like peptide-1 in the pathogenesis of type 2 diabetes. Diabetes. 53 Suppl 3 [PubMed]
Nauck MA, Vardarli I, Deacon CF, Holst JJ, Meier JJ. (2011). Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down? Diabetologia. 54 [PubMed]
Okuma Y, Reisine T. (1992). Immunoprecipitation of alpha 2a-adrenergic receptor-GTP-binding protein complexes using GTP-binding protein selective antisera. Changes in receptor/GTP-binding protein interaction following agonist binding. The Journal of biological chemistry. 267 [PubMed]
Pacini G, Thomaseth K, Ahrén B. (2010). Dissociated effects of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide-1 on beta-cell secretion and insulin clearance in mice. Metabolism: clinical and experimental. 59 [PubMed]
Pan M, Yang G, Cui X, Yang SN. (2011). Subthreshold a2-adrenergic activation counteracts glucagon-like peptide-1 potentiation of glucose-stimulated insulin secretion. Experimental diabetes research. 2011 [PubMed]
Pedersen MG, Cortese G, Eliasson L. (2011). Mathematical modeling and statistical analysis of calcium-regulated insulin granule exocytosis in ß-cells from mice and humans. Progress in biophysics and molecular biology. 107 [PubMed]
Peercy BE, Sherman AS. (2010). How pancreatic beta-cells discriminate long and short timescale cAMP signals. Biophysical journal. 99 [PubMed]
Peercy BE, Sherman AS, Bertram R. (2015). Modeling of glucose-induced cAMP oscillations in pancreatic ß cells: cAMP rocks when metabolism rolls. Biophysical journal. 109 [PubMed]
Porte D, Graber AL, Kuzuya T, Williams RH. (1966). The effect of epinephrine on immunoreactive insulin levels in man. The Journal of clinical investigation. 45 [PubMed]
Prentki M, Matschinsky FM, Madiraju SR. (2013). Metabolic signaling in fuel-induced insulin secretion. Cell metabolism. 18 [PubMed]
Putney JW. (2009). Capacitative calcium entry: from concept to molecules. Immunological reviews. 231 [PubMed]
Pyne NJ, Furman BL. (2003). Cyclic nucleotide phosphodiesterases in pancreatic islets. Diabetologia. 46 [PubMed]
Qian J et al. (2014). Differential requirements of arrestin-3 and clathrin for ligand-dependent and -independent internalization of human G protein-coupled receptor 40. Cellular signalling. 26 [PubMed]
Rajan S et al. (2015). Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic ß-cells via protein kinase A. Molecular metabolism. 4 [PubMed]
Rajan S, Torres J, Thompson MS, Philipson LH. (2012). SUMO downregulates GLP-1-stimulated cAMP generation and insulin secretion. American journal of physiology. Endocrinology and metabolism. 302 [PubMed]
Raoux M et al. (2015). Multilevel control of glucose homeostasis by adenylyl cyclase 8. Diabetologia. 58 [PubMed]
Ravier MA et al. (2011). Mechanisms of control of the free Ca2+ concentration in the endoplasmic reticulum of mouse pancreatic ß-cells: interplay with cell metabolism and [Ca2+]c and role of SERCA2b and SERCA3. Diabetes. 60 [PubMed]
Roger B et al. (2011). Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells. Diabetologia. 54 [PubMed]
Rorsman P, Braun M, Zhang Q. (2012). Regulation of calcium in pancreatic a- and ß-cells in health and disease. Cell calcium. 51 [PubMed]
Rorsman P, Eliasson L, Kanno T, Zhang Q, Gopel S. (2011). Electrophysiology of pancreatic ß-cells in intact mouse islets of Langerhans. Progress in biophysics and molecular biology. 107 [PubMed]
Rosengren AH et al. (2010). Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes. Science (New York, N.Y.). 327 [PubMed]
Ruiz de Azua I, Gautam D, Guettier JM, Wess J. (2011). Novel insights into the function of ß-cell M3 muscarinic acetylcholine receptors: therapeutic implications. Trends in endocrinology and metabolism: TEM. 22 [PubMed]
Sassmann A et al. (2010). The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice. The Journal of clinical investigation. 120 [PubMed]
Saucerman JJ, Brunton LL, Michailova AP, McCulloch AD. (2003). Modeling beta-adrenergic control of cardiac myocyte contractility in silico. The Journal of biological chemistry. 278 [PubMed]
Schelshorn D et al. (2012). Lateral allosterism in the glucagon receptor family: glucagon-like peptide 1 induces G-protein-coupled receptor heteromer formation. Molecular pharmacology. 81 [PubMed]
Schnell S, Schaefer M, Schöfl C. (2007). Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40. Molecular and cellular endocrinology. 263 [PubMed]
Schöfl C, Börger J, Lange S, von zur Mühlen A, Brabant G. (2000). Energetic requirement of carbachol-induced Ca2+ signaling in single mouse beta-cells. Endocrinology. 141 [PubMed]
Seed Ahmed M et al. (2012). Increased expression of adenylyl cyclase 3 in pancreatic islets and central nervous system of diabetic Goto-Kakizaki rats: a possible regulatory role in glucose homeostasis. Islets. 4 [PubMed]
Seifert R, Wenzel-Seifert K. (2002). Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors. Naunyn-Schmiedeberg's archives of pharmacology. 366 [PubMed]
Seino S, Shibasaki T. (2005). PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. Physiological reviews. 85 [PubMed]
Seino S, Takahashi H, Fujimoto W, Shibasaki T. (2009). Roles of cAMP signalling in insulin granule exocytosis. Diabetes, obesity & metabolism. 11 Suppl 4 [PubMed]
Seino Y et al. (2013). Cephalic phase insulin secretion is KATP channel independent. The Journal of endocrinology. 218 [PubMed]
Selway J et al. (2012). Evidence that Ca2+ within the microdomain of the L-type voltage gated Ca2+ channel activates ERK in MIN6 cells in response to glucagon-like peptide-1. PloS one. 7 [PubMed]
Selway JL, Moore CE, Mistry R, John Challiss RA, Herbert TP. (2012). Molecular mechanisms of muscarinic acetylcholine receptor-stimulated increase in cytosolic free Ca(2+) concentration and ERK1/2 activation in the MIN6 pancreatic ß-cell line. Acta diabetologica. 49 [PubMed]
Shea LD, Neubig RR, Linderman JJ. (2000). Timing is everything the role of kinetics in G protein activation. Life sciences. 68 [PubMed]
Shenoy SK, Lefkowitz RJ. (2003). Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination. The Journal of biological chemistry. 278 [PubMed]
Shu L et al. (2009). Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function. Human molecular genetics. 18 [PubMed]
Shyng SL, Nichols CG. (1998). Membrane phospholipid control of nucleotide sensitivity of KATP channels. Science (New York, N.Y.). 282 [PubMed]
Smolen P, Baxter DA, Byrne JH. (2006). A model of the roles of essential kinases in the induction and expression of late long-term potentiation. Biophysical journal. 90 [PubMed]
Smrcka AV, Brown JH, Holz GG. (2012). Role of phospholipase Ce in physiological phosphoinositide signaling networks. Cellular signalling. 24 [PubMed]
Srinivasan S et al. (2004). Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans. The Journal of clinical investigation. 114 [PubMed]
Steiner D et al. (2005). Regulation of adenylate cyclase type VIII splice variants by acute and chronic Gi/o-coupled receptor activation. The Biochemical journal. 386 [PubMed]
Sunahara RK, Dessauer CW, Whisnant RE, Kleuss C, Gilman AG. (1997). Interaction of Gsalpha with the cytosolic domains of mammalian adenylyl cyclase. The Journal of biological chemistry. 272 [PubMed]
Sunil V et al. (2014). CNX-011-67, a novel GPR40 agonist, enhances glucose responsiveness, insulin secretion and islet insulin content in n-STZ rats and in islets from type 2 diabetic patients. BMC pharmacology & toxicology. 15 [PubMed]
Suzuki Y et al. (2006). Glucagon-like peptide 1 activates protein kinase C through Ca2+-dependent activation of phospholipase C in insulin-secreting cells. The Journal of biological chemistry. 281 [PubMed]
Swayne LA et al. (2009). The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic beta-cell line. EMBO reports. 10 [PubMed]
Syme CA, Zhang L, Bisello A. (2006). Caveolin-1 regulates cellular trafficking and function of the glucagon-like Peptide 1 receptor. Molecular endocrinology (Baltimore, Md.). 20 [PubMed]
Sánchez-Fernández G et al. (2014). Gaq signalling: the new and the old. Cellular signalling. 26 [PubMed]
Takeda Y et al. (2011). Systems analysis of GLP-1 receptor signaling in pancreatic ß-cells. American journal of physiology. Cell physiology. 301 [PubMed]
Tamarina NA, Kuznetsov A, Fridlyand LE, Philipson LH. (2005). Delayed-rectifier (KV2.1) regulation of pancreatic beta-cell calcium responses to glucose: inhibitor specificity and modeling. American journal of physiology. Endocrinology and metabolism. 289 [PubMed]
Tamarina NA, Kuznetsov A, Philipson LH. (2008). Reversible translocation of EYFP-tagged STIM1 is coupled to calcium influx in insulin secreting beta-cells. Cell calcium. 44 [PubMed]
Tamarina NA, Kuznetsov A, Rhodes CJ, Bindokas VP, Philipson LH. (2005). Inositol (1,4,5)-trisphosphate dynamics and intracellular calcium oscillations in pancreatic beta-cells. Diabetes. 54 [PubMed]
Tengholm A. (2012). Cyclic AMP dynamics in the pancreatic ß-cell. Upsala journal of medical sciences. 117 [PubMed]
Thore S, Dyachok O, Gylfe E, Tengholm A. (2005). Feedback activation of phospholipase C via intracellular mobilization and store-operated influx of Ca2+ in insulin-secreting beta-cells. Journal of cell science. 118 [PubMed]
Thore S, Wuttke A, Tengholm A. (2007). Rapid turnover of phosphatidylinositol-4,5-bisphosphate in insulin-secreting cells mediated by Ca2+ and the ATP-to-ADP ratio. Diabetes. 56 [PubMed]
Tian Y, Laychock SG. (2001). Protein kinase C and calcium regulation of adenylyl cyclase in isolated rat pancreatic islets. Diabetes. 50 [PubMed]
Tornehave D, Kristensen P, Rømer J, Knudsen LB, Heller RS. (2008). Expression of the GLP-1 receptor in mouse, rat, and human pancreas. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 56 [PubMed]
Tsalkova T, Blumenthal DK, Mei FC, White MA, Cheng X. (2009). Mechanism of Epac activation: structural and functional analyses of Epac2 hinge mutants with constitutive and reduced activities. The Journal of biological chemistry. 284 [PubMed]
Tsuga H, Okuno E, Kameyama K, Haga T. (1998). Sequestration of human muscarinic acetylcholine receptor hm1-hm5 subtypes: effect of G protein-coupled receptor kinases GRK2, GRK4, GRK5 and GRK6. The Journal of pharmacology and experimental therapeutics. 284 [PubMed]
Vanderheyden V et al. (2009). Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation. Biochimica et biophysica acta. 1793 [PubMed]
Varadi A, Rutter GA. (2002). Dynamic imaging of endoplasmic reticulum Ca2+ concentration in insulin-secreting MIN6 Cells using recombinant targeted cameleons: roles of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2 and ryanodine receptors. Diabetes. 51 Suppl 1 [PubMed]
Vilardaga JP. (2010). Theme and variations on kinetics of GPCR activation/deactivation. Journal of receptor and signal transduction research. 30 [PubMed]
Vilardaga JP, Romero G, Feinstein TN, Wehbi VL. (2013). Kinetics and dynamics in the G protein-coupled receptor signaling cascade. Methods in enzymology. 522 [PubMed]
Vines CM. (2012). Phospholipase C. Advances in experimental medicine and biology. 740 [PubMed]
Vollert S et al. (2012). The glucose-lowering effects of the PDE4 inhibitors roflumilast and roflumilast-N-oxide in db/db mice. Diabetologia. 55 [PubMed]
Wagner J, Keizer J. (1994). Effects of rapid buffers on Ca2+ diffusion and Ca2+ oscillations. Biophysical journal. 67 [PubMed]
Whalley NM, Pritchard LE, Smith DM, White A. (2011). Processing of proglucagon to GLP-1 in pancreatic a-cells: is this a paracrine mechanism enabling GLP-1 to act on ß-cells? The Journal of endocrinology. 211 [PubMed]
Wheeler MB et al. (1999). Characterization of the carboxyl-terminal domain of the rat glucose-dependent insulinotropic polypeptide (GIP) receptor. A role for serines 426 and 427 in regulating the rate of internalization. The Journal of biological chemistry. 274 [PubMed]
Whitaker GM, Lynn FC, McIntosh CH, Accili EA. (2012). Regulation of GIP and GLP1 receptor cell surface expression by N-glycosylation and receptor heteromerization. PloS one. 7 [PubMed]
Widmann C, Bürki E, Dolci W, Thorens B. (1994). Signal transduction by the cloned glucagon-like peptide-1 receptor: comparison with signaling by the endogenous receptors of beta cell lines. Molecular pharmacology. 45 [PubMed]
Willard FS, Sloop KW. (2012). Physiology and emerging biochemistry of the glucagon-like peptide-1 receptor. Experimental diabetes research. 2012 [PubMed]
Woodroffe PJ, Bridge LJ, King JR, Chen CY, Hill SJ. (2010). Modelling of the activation of G-protein coupled receptors: drug free constitutive receptor activity. Journal of mathematical biology. 60 [PubMed]
Woolf PJ, Kenakin TP, Linderman JJ. (2001). Uncovering biases in high throughput screens of G-protein coupled receptors. Journal of theoretical biology. 208 [PubMed]
Wuttke A, Sågetorp J, Tengholm A. (2010). Distinct plasma-membrane PtdIns(4)P and PtdIns(4,5)P2 dynamics in secretagogue-stimulated beta-cells. Journal of cell science. 123 [PubMed]
Xia Z, Storm DR. (1997). Calmodulin-regulated adenylyl cyclases and neuromodulation. Current opinion in neurobiology. 7 [PubMed]
Xie LH, Horie M, Takano M. (1999). Phospholipase C-linked receptors regulate the ATP-sensitive potassium channel by means of phosphatidylinositol 4,5-bisphosphate metabolism. Proceedings of the National Academy of Sciences of the United States of America. 96 [PubMed]
Yabe D, Seino Y. (2011). Two incretin hormones GLP-1 and GIP: comparison of their actions in insulin secretion and ß cell preservation. Progress in biophysics and molecular biology. 107 [PubMed]
Yada T, Hamakawa N, Yaekura K. (1995). Two distinct modes of Ca2+ signalling by ACh in rat pancreatic beta-cells: concentration, glucose dependence and Ca2+ origin. The Journal of physiology. 488 ( Pt 1) [PubMed]
Yamazaki H, Zawalich KC, Zawalich WS. (2010). Physiologic implications of phosphoinositides and phospholipase C in the regulation of insulin secretion. Journal of nutritional science and vitaminology. 56 [PubMed]
Zawalich WS, Bonnet-Eymard M, Zawalich KC. (2000). Insulin secretion, inositol phosphate levels, and phospholipase C isozymes in rodent pancreatic islets. Metabolism: clinical and experimental. 49 [PubMed]
Zhou YJ, Song YL, Zhou H, Li Y. (2012). Linoleic acid activates GPR40/FFA1 and phospholipase C to increase [Ca2+]i release and insulin secretion in islet beta-cells. Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih. 27 [PubMed]
Ziegler N, Bätz J, Zabel U, Lohse MJ, Hoffmann C. (2011). FRET-based sensors for the human M1-, M3-, and M5-acetylcholine receptors. Bioorganic & medicinal chemistry. 19 [PubMed]
de Heer J, Holst JJ. (2007). Sulfonylurea compounds uncouple the glucose dependence of the insulinotropic effect of glucagon-like peptide 1. Diabetes. 56 [PubMed]