Respiratory central pattern generator including Kolliker-Fuse nucleus (Wittman et al 2019)


We present three highly reduced conductance-based models for the core of the respiratory CPG. All successfully simulate respiratory outputs across eupnoeic and vagotomized conditions and show that loss of inhibition to the pontine Kolliker-Fuse nucleus reproduces the key respiratory alterations associated with Rett syndrome.

Model Type: Realistic Network

Region(s) or Organism(s): Brainstem

Currents: I Na,p

Receptors: AMPA; GabaA; Glycine

Transmitters: Glutamate; Gaba; Glycine

Model Concept(s): Respiratory control

Simulation Environment: XPPAUT; MATLAB

Implementer(s): Wittman, Samuel [swittman52 at gmail.com]

References:

Wittman S, Abdala AP, Rubin JE. (2019). Reduced computational modelling of K├Âlliker-Fuse contributions to breathing patterns in Rett syndrome. The Journal of physiology. 597 [PubMed]


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