Ave. neuron model for slow-wave sleep in cortex Tatsuki 2016 Yoshida 2018 Rasmussen 2017 (all et al)

Averaged neuron(AN) model is a conductance-based (Hodgkin-Huxley type) neuron model which includes a mean-field approximation of a population of neurons. You can simulate previous models (AN model: Tatsuki et al., 2016 and SAN model: Yoshida et al., 2018), and various models with 'X model' based on channel and parameter modules. Also, intracellular and extracellular ion concentration can be taken into consideration using the Nernst equation (See Ramussen et al., 2017).

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Mouse; Neocortex

Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex layer 5 interneuron

Currents: I Potassium; Ca pump; I A; I Calcium; I K,Ca; I K,leak; I Na,p; I Sodium; Kir; IK Bkca; IK Skca

Receptors: NMDA; AMPA; GabaA

Transmitters: Gaba; Glutamate

Model Concept(s): Sleep; Bifurcation; Activity Patterns; Action Potentials; Bursting; Calcium dynamics; Persistent activity; Brain Rhythms; Sleep-Wake transition

Simulation Environment: Python

Implementer(s): Tatsuki, Fumiya [tatsuki-tky at umin.ac.jp]; Yoshida, Kensuke [kensuyoshida-tky at umin.ac.jp]; Yamada, Tetsuya ; Katsumata, Takahiro [alextfkd at m.u-tokyo.ac.jp]; Shi, Shoi [sshoi0322-tky at umin.ac.jp] ; Ueda, R, Hiroki [hiroki.ueda at nifty.com]


Tatsuki F et al. (2016). Involvement of Ca(2+)-Dependent Hyperpolarization in Sleep Duration in Mammals. Neuron. 90 [PubMed]

Yoshida K et al. (2018). Leak potassium channels regulate sleep duration. Proceedings of the National Academy of Sciences of the United States of America. 115 [PubMed]

Rasmussen R, Jensen MH, Heltberg ML. (2017). Chaotic Dynamics Mediate Brain State Transitions, Driven by Changes in Extracellular Ion Concentrations. Cell systems. 5 [PubMed]

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