Hippocampal CA1 microcircuit model including somatic and dendritic inhibition

Here, we investigate the role of (dis)inhibition on the lateral entorhinal cortex (LEC) induced dendritic spikes on hippocampal CA1 pyramidal cells. The circuit model consists of pyramidal, SST+, CCK+, CR+/VIP+, and CCK+/VIP+ cells.

Model Type: Dendrite

Region(s) or Organism(s): Mouse; Hippocampus

Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA1 stratum oriens lacunosum-moleculare interneuron ; Hippocampus CA1 basket cell - CCK/VIP; Hippocampal CA1 CR/VIP cell

Currents: Ca pump; I A; I Calcium; I h; I K; I K,Ca; I Na,t; I M; IK Bkca; IK Skca; I Na, leak

Receptors: AMPA; NMDA; Gaba

Model Concept(s): Active Dendrites; Dendritic Action Potentials

Simulation Environment: NEURON

Implementer(s): Chavlis, Spyridon [schavlis at imbb.forth.gr]


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