Here, we investigate the role of (dis)inhibition on the lateral entorhinal cortex (LEC) induced dendritic spikes on hippocampal CA1 pyramidal cells. The circuit model consists of pyramidal, SST+, CCK+, CR+/VIP+, and CCK+/VIP+ cells.
Model Type: Dendrite
Region(s) or Organism(s): Mouse; Hippocampus
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA1 stratum oriens lacunosum-moleculare interneuron ; Hippocampus CA1 basket cell - CCK/VIP; Hippocampal CA1 CR/VIP cell
Currents: Ca pump; I A; I Calcium; I h; I K; I K,Ca; I Na,t; I M; IK Bkca; IK Skca; I Na, leak
Model Concept(s): Active Dendrites; Dendritic Action Potentials
Simulation Environment: NEURON
Implementer(s): Chavlis, Spyridon [schavlis at imbb.forth.gr]
References:
Bilash OM, Chavlis S, Johnson CD, Poirazi P, Basu J. (2023). Lateral entorhinal cortex inputs modulate hippocampal dendritic excitability by recruiting a local disinhibitory microcircuit. Cell reports. 42 [PubMed]