Depolarization Enhacement of Dendritic Spike Propagation (Bock et al 2022)

This model shows that small subthreshold depolarization of the soma powerfully enhances the propagation of dendritic spikes, through inactivation of dendritic A-type potassium channels.

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Mouse

Cell Type(s): Hippocampus CA1 pyramidal GLU cell

Currents: I R; I T low threshold; I A; I h; I K; I K,Ca

Model Concept(s): Calcium dynamics; Synaptic Plasticity

Simulation Environment: NEURON; Python

Implementer(s): Negrean, Adrian [negreanadrian at]; Bock, Tobias [htb2110 at]


Bock T, Negrean A, Siegelbaum SA. (2022). Somatic depolarization enhances hippocampal CA1 dendritic spike propagation and distal input-driven synaptic plasticity The Journal of neuroscience : the official journal of the Society for Neuroscience. 42 [PubMed]

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