This model shows that small subthreshold depolarization of the soma powerfully enhances the propagation of dendritic spikes, through inactivation of dendritic A-type potassium channels.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Mouse
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Currents: I R; I T low threshold; I A; I h; I K; I K,Ca
Model Concept(s): Calcium dynamics; Synaptic Plasticity
Simulation Environment: NEURON; Python
Implementer(s): Negrean, Adrian [negreanadrian at gmail.com]; Bock, Tobias [htb2110 at columbia.edu]
References:
Bock T, Negrean A, Siegelbaum SA. (2022). Somatic depolarization enhances hippocampal CA1 dendritic spike propagation and distal input-driven synaptic plasticity The Journal of neuroscience : the official journal of the Society for Neuroscience. 42 [PubMed]