Abbott GW et al. (1999). MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell. 97 [PubMed]
Antzelevitch C, Yan G, Shimuzu W, Burashnikov P. (2000). Electrical heterogeneity, the ECG, and cardiac arrhythmias Cardiac electrophysiology: from cell to bedside.
Balser JR, Roden DM, Bennett PB. (1990). Global parameter optimization for cardiac potassium channel gating models. Biophysical journal. 57 [PubMed]
Chen J, Zou A, Splawski I, Keating MT, Sanguinetti MC. (1999). Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation. The Journal of biological chemistry. 274 [PubMed]
Clancy CE, Rudy Y. (1999). Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia. Nature. 400 [PubMed]
Curran ME et al. (1995). A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell. 80 [PubMed]
El-Sherif N, Chinushi M, Caref EB, Restivo M. (1997). Electrophysiological mechanism of the characteristic electrocardiographic morphology of torsade de pointes tachyarrhythmias in the long-QT syndrome: detailed analysis of ventricular tridimensional activation patterns. Circulation. 96 [PubMed]
Faber GM, Rudy Y. (2000). Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study. Biophysical journal. 78 [PubMed]
Ficker E, Jarolimek W, Kiehn J, Baumann A, Brown AM. (1998). Molecular determinants of dofetilide block of HERG K+ channels. Circulation research. 82 [PubMed]
HODGKIN AL, HUXLEY AF. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. The Journal of physiology. 117 [PubMed]
Hancox JC, Levi AJ, Witchel HJ. (1998). Time course and voltage dependence of expressed HERG current compared with native "rapid" delayed rectifier K current during the cardiac ventricular action potential. Pflugers Archiv : European journal of physiology. 436 [PubMed]
Hoorntje T et al. (1999). Homozygous premature truncation of the HERG protein : the human HERG knockout. Circulation. 100 [PubMed]
Keating MT, Sanguinetti MC. (1996). Molecular genetic insights into cardiovascular disease. Science (New York, N.Y.). 272 [PubMed]
Kiehn J, Lacerda AE, Brown AM. (1999). Pathways of HERG inactivation. The American journal of physiology. 277 [PubMed]
Lees-Miller JP, Duan Y, Teng GQ, Thorstad K, Duff HJ. (2000). Novel gain-of-function mechanism in K(+) channel-related long-QT syndrome: altered gating and selectivity in the HERG1 N629D mutant. Circ Res. 86
Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circulation research. 74 [PubMed]
Morais Cabral JH et al. (1998). Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain. Cell. 95 [PubMed]
Moss AJ et al. (1999). Comparison of clinical and genetic variables of cardiac events associated with loud noise versus swimming among subjects with the long QT syndrome. The American journal of cardiology. 84 [PubMed]
Nakajima T et al. (1998). Novel mechanism of HERG current suppression in LQT2: shift in voltage dependence of HERG inactivation. Circulation research. 83 [PubMed]
Roden DM, Balser JR. (1999). A plethora of mechanisms in the HERG-related long QT syndrome. Genetics meets electrophysiology. Cardiovascular research. 44 [PubMed]
Roden DM, Yang T, Snyders DJ. (1997). Rapid inactivation determines the rectification and [K+]o dependence of the rapid component of the delayed rectifier K+ current in cardiac cells. Circ Res. 80
Sanguinetti MC, Curran ME, Spector PS, Keating MT. (1996). Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia. Proceedings of the National Academy of Sciences of the United States of America. 93 [PubMed]
Sanguinetti MC, Jurkiewicz NK. (1990). Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents. The Journal of general physiology. 96 [PubMed]
Sanguinetti MC, Xu QP. (1999). Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes. J Physiol. 514 ( Pt 3)
Schwartz PJ, Priori S. (2000). The Long-QT syndrome Cardiac electrophysiology: from cell to bedside (3rd ed).
Schwartz PJ et al. (1995). Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy. Circulation. 92 [PubMed]
Shibasaki T. (1987). Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart. The Journal of physiology. 387 [PubMed]
Shrier A, Petrecca K, Atanasiu R, Akhavan A. (1999). N-linked glycosylation sites determine HERG channel surface membrane expression. J Physiol. 515 ( Pt 1)
Smith PL, Baukrowitz T, Yellen G. (1996). The inward rectification mechanism of the HERG cardiac potassium channel. Nature. 379 [PubMed]
Viswanathan PC, Rudy Y. (1999). Pause induced early afterdepolarizations in the long QT syndrome: a simulation study. Cardiovascular research. 42 [PubMed]
Viswanathan PC, Rudy Y. (2000). Cellular arrhythmogenic effects of congenital and acquired long-QT syndrome in the heterogeneous myocardium. Circulation. 101 [PubMed]
Viswanathan PC, Shaw RM, Rudy Y. (1999). Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study. Circulation. 99 [PubMed]
Wang S, Liu S, Morales MJ, Strauss HC, Rasmusson RL. (1997). A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes. The Journal of physiology. 502 ( Pt 1) [PubMed]
Wilde AA et al. (1999). Auditory stimuli as a trigger for arrhythmic events differentiate HERG-related (LQTS2) patients from KVLQT1-related patients (LQTS1). Journal of the American College of Cardiology. 33 [PubMed]
Xu J, Li M, Li X. (1997). The human delta1261 mutation of the HERG potassium channel results in a truncated protein that contains a subunit interaction domain and decreases the channel expression. J Biol Chem. 272
Zeng J, Laurita KR, Rosenbaum DS, Rudy Y. (1995). Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. Circulation research. 77 [PubMed]
Zeng J, Rudy Y. (1995). Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence. Biophysical journal. 68 [PubMed]
Zhou Z, Gong Q, Epstein ML, January CT. (1998). HERG channel dysfunction in human long QT syndrome. Intracellular transport and functional defects. The Journal of biological chemistry. 273 [PubMed]
Zhou Z et al. (1998). Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature. Biophysical journal. 74 [PubMed]
Clancy CE, Rudy Y. (2002). Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism. Circulation. 105 [PubMed]
Mahajan A et al. (2008). A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates. Biophysical journal. 94 [PubMed]
Sung RJ, Wu SN, Wu JS, Chang HD, Luo CH. (2006). Electrophysiological mechanisms of ventricular arrhythmias in relation to Andersen-Tawil syndrome under conditions of reduced IK1: a simulation study. American journal of physiology. Heart and circulatory physiology. 291 [PubMed]
Wang YJ, Sung RJ, Lin MW, Wu SN. (2006). Contribution of BK(Ca)-channel activity in human cardiac fibroblasts to electrical coupling of cardiomyocytes-fibroblasts. The Journal of membrane biology. 213 [PubMed]