We consider a simple, minimal model for signal-induced Ca2+ oscillations based on Ca(2+)-induced Ca2+ release. The model takes into account the existence of two pools of intracellular Ca2+, namely, one sensitive to inositol 1,4,5 trisphosphate (InsP3) whose synthesis is elicited by the stimulus, and one insensitive to InsP3. See paper for more and details.
Model Type: Molecular Network
Currents: I Calcium
Transmitters: Ions
Model Concept(s): Oscillations; Simplified Models; Signaling pathways; Calcium dynamics; Calcium waves
Simulation Environment: XPPAUT
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]; Chang, Han-Dong; Wu, Jiun-Shian [coolneon at gmail.com]
References:
Dupont G, Berridge MJ, Goldbeter A. (1991). Signal-induced Ca2+ oscillations: properties of a model based on Ca(2+)-induced Ca2+ release. Cell calcium. 12 [PubMed]