NEURON mod files from N. Poolos, M. Migliore, and D. Johnston, Nature Neuroscience (2002). The experimental and modeling results in this paper demonstrate for the first time that neuronal excitability can be altered by pharmaceuticals acting selectively on dendrites, and suggest an important role for Ih in controlling dendritic excitability and epileptogenesis.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Currents: I Na,t; I A; I K; I h
Receptors: AMPA
Model Concept(s): Ion Channel Kinetics; Active Dendrites; Detailed Neuronal Models; Action Potentials
Simulation Environment: NEURON
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu]
References:
Poolos NP, Migliore M, Johnston D. (2002). Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites. Nature neuroscience. 5 [PubMed]