CA1 pyramidal neuron: effects of Lamotrigine on dendritic excitability (Poolos et al 2002)


Poolos NP, Migliore M, Johnston D. (2002). Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites. Nature neuroscience. 5 [PubMed]

See more from authors: Poolos NP · Migliore M · Johnston D

References and models cited by this paper

Beaumont V, Zucker RS. (2000). Enhancement of synaptic transmission by cyclic AMP modulation of presynaptic Ih channels. Nature neuroscience. 3 [PubMed]

Calabrese JR. (1999). Lamotrigine and the treatment of bipolar disorder. Introduction. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 9 Suppl 4 [PubMed]

Chen K et al. (2001). Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability. Nature medicine. 7 [PubMed]

Chen S, Wang J, Siegelbaum SA. (2001). Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide. The Journal of general physiology. 117 [PubMed]

Colbert CM, Magee JC, Hoffman DA, Johnston D. (1997). Slow recovery from inactivation of Na+ channels underlies the activity-dependent attenuation of dendritic action potentials in hippocampal CA1 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 17 [PubMed]

Coulter DA. (1997). Antiepileptic drug cellular mechanisms of action: where does lamotrigine fit in? Journal of child neurology. 12 Suppl 1 [PubMed]

Golding NL, Spruston N. (1998). Dendritic sodium spikes are variable triggers of axonal action potentials in hippocampal CA1 pyramidal neurons. Neuron. 21 [PubMed]

Harris KM, Fiala JC. (1999). In Dendrites.

Harris NC, Constanti A. (1995). Mechanism of block by ZD 7288 of the hyperpolarization-activated inward rectifying current in guinea pig substantia nigra neurons in vitro. Journal of neurophysiology. 74 [PubMed]

Hines ML, Carnevale NT. (1997). The NEURON simulation environment. Neural computation. 9 [PubMed]

Häusser M, Spruston N, Stuart GJ. (2000). Diversity and dynamics of dendritic signaling. Science (New York, N.Y.). 290 [PubMed]

Johnston D et al. (2000). Dendritic potassium channels in hippocampal pyramidal neurons. The Journal of physiology. 525 Pt 1 [PubMed]

Johnston D, Magee JC, Colbert CM, Cristie BR. (1996). Active properties of neuronal dendrites. Annual review of neuroscience. 19 [PubMed]

Kuo CC, Lu L. (1997). Characterization of lamotrigine inhibition of Na+ channels in rat hippocampal neurones. British journal of pharmacology. 121 [PubMed]

Lupica CR, Bell JA, Hoffman AF, Watson PL. (2001). Contribution of the hyperpolarization-activated current (I(h)) to membrane potential and GABA release in hippocampal interneurons. Journal of neurophysiology. 86 [PubMed]

Magee J, Hoffman D, Colbert C, Johnston D. (1998). Electrical and calcium signaling in dendrites of hippocampal pyramidal neurons. Annual review of physiology. 60 [PubMed]

Magee JC. (1998). Dendritic hyperpolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18 [PubMed]

Magee JC. (1999). Dendritic lh normalizes temporal summation in hippocampal CA1 neurons. Nature neuroscience. 2 [PubMed]

Messenheimer J. (1996). in The Treatment of Epilepsy Principles And Practice.

Migliore M, Hoffman DA, Magee JC, Johnston D. (1999). Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons. Journal of computational neuroscience. 7 [PubMed]

Pape HC. (1996). Queer current and pacemaker: the hyperpolarization-activated cation current in neurons. Annual review of physiology. 58 [PubMed]

Poolos NP, Johnston D. (1999). Calcium-activated potassium conductances contribute to action potential repolarization at the soma but not the dendrites of hippocampal CA1 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]

Santoro B et al. (2000). Molecular and functional heterogeneity of hyperpolarization-activated pacemaker channels in the mouse CNS. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]

Shorvon SD. (2000). Handbook Of Epilepsy Treatment.

Stefani A, Spadoni F, Siniscalchi A, Bernardi G. (1996). Lamotrigine inhibits Ca2+ currents in cortical neurons: functional implications. European journal of pharmacology. 307 [PubMed]

Stuart G, Spruston N. (1998). Determinants of voltage attenuation in neocortical pyramidal neuron dendrites. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18 [PubMed]

Stuart G, Spruston N, Sakmann B, Häusser M. (1997). Action potential initiation and backpropagation in neurons of the mammalian CNS. Trends in neurosciences. 20 [PubMed]

Wang SJ, Sihra TS, Gean PW. (2001). Lamotrigine inhibition of glutamate release from isolated cerebrocortical nerve terminals (synaptosomes) by suppression of voltage-activated calcium channel activity. Neuroreport. 12 [PubMed]

White HS. (1997). In The Epilepsies. 2

Xie X, Lancaster B, Peakman T, Garthwaite J. (1995). Interaction of the antiepileptic drug lamotrigine with recombinant rat brain type IIA Na+ channels and with native Na+ channels in rat hippocampal neurones. Pflugers Archiv : European journal of physiology. 430 [PubMed]

References and models that cite this paper

Angelo K, London M, Christensen SR, Häusser M. (2007). Local and global effects of I(h) distribution in dendrites of mammalian neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Antunes G, Faria da Silva SF, Simoes de Souza FM. (2018). Mirror Neurons Modeled Through Spike-Timing-Dependent Plasticity are Affected by Channelopathies Associated with Autism Spectrum Disorder. International journal of neural systems. 28 [PubMed]

Basak R, Narayanan R. (2018). Active dendrites regulate the spatiotemporal spread of signaling microdomains. PLoS computational biology. 14 [PubMed]

Berzhanskaya J, Chernyy N, Gluckman BJ, Schiff SJ, Ascoli GA. (2013). Modulation of hippocampal rhythms by subthreshold electric fields and network topology. Journal of computational neuroscience. 34 [PubMed]

Bezaire MJ, Raikov I, Burk K, Vyas D, Soltesz I. (2016). Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit. eLife. 5 [PubMed]

Bogaard A, Parent J, Zochowski M, Booth V. (2009). Interaction of cellular and network mechanisms in spatiotemporal pattern formation in neuronal networks. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]

Booth V, Poe GR. (2006). Input source and strength influences overall firing phase of model hippocampal CA1 pyramidal cells during theta: relevance to REM sleep reactivation and memory consolidation. Hippocampus. 16 [PubMed]

Carnevale NT, Hines M. (2003). Personal Communication of NEURON bibliography .

Das A, Narayanan R. (2015). Active dendrites mediate stratified gamma-range coincidence detection in hippocampal model neurons. The Journal of physiology. 593 [PubMed]

Dewell RB, Gabbiani F. (2018). Biophysics of object segmentation in a collision-detecting neuron. eLife. 7 [PubMed]

Duggins P, Stewart TC, Choo X, Eliasmith C. (2017). The Effects of Guanfacine and Phenylephrine on a Spiking Neuron Model of Working Memory. Topics in cognitive science. 9 [PubMed]

Ferrante M, Blackwell KT, Migliore M, Ascoli GA. (2008). Computational models of neuronal biophysics and the characterization of potential neuropharmacological targets. Current medicinal chemistry. 15 [PubMed]

Gabbiani F, Krapp HG. (2006). Spike-frequency adaptation and intrinsic properties of an identified, looming-sensitive neuron. Journal of neurophysiology. 96 [PubMed]

Li X, Ascoli GA. (2006). Computational simulation of the input-output relationship in hippocampal pyramidal cells. Journal of computational neuroscience. 21 [PubMed]

Marcelin B et al. (2009). h channel-dependent deficit of theta oscillation resonance and phase shift in temporal lobe epilepsy. Neurobiology of disease. 33 [PubMed]

Migliore M, Ferrante M, Ascoli GA. (2005). Signal propagation in oblique dendrites of CA1 pyramidal cells. Journal of neurophysiology. 94 [PubMed]

Migliore M, Messineo L, Ferrante M. (2004). Dendritic Ih selectively blocks temporal summation of unsynchronized distal inputs in CA1 pyramidal neurons. Journal of computational neuroscience. 16 [PubMed]

Migliore M, Novara G, Tegolo D. (2008). Single neuron binding properties and the magical number 7. Hippocampus. 18 [PubMed]

Mäki-Marttunen T, Mäki-Marttunen V. (2022). Excitatory and inhibitory effects of HCN channel modulation on excitability of layer V pyramidal cells PLoS computational biology. 18 [PubMed]

Neymotin SA et al. (2013). Ih tunes theta/gamma oscillations and cross-frequency coupling in an in silico CA3 model. PloS one. 8 [PubMed]

Neymotin SA et al. (2016). Calcium regulation of HCN channels supports persistent activity in a multiscale model of neocortex. Neuroscience. 316 [PubMed]

Parekh R, Ascoli GA. (2013). Neuronal morphology goes digital: a research hub for cellular and system neuroscience. Neuron. 77 [PubMed]

Shah MM, Migliore M, Brown DA. (2011). Differential effects of Kv7 (M-) channels on synaptic integration in distinct subcellular compartments of rat hippocampal pyramidal neurons. The Journal of physiology. 589 [PubMed]

Soltesz I, Armstrong C, Raikov I, Bezaire M, Burk K. (2016). SimTracker tool and code template to design, manage and analyze neural network model simulations in parallel NEURON bioRxiv.

Steephen JE, Manchanda R. (2009). Differences in biophysical properties of nucleus accumbens medium spiny neurons emerging from inactivation of inward rectifying potassium currents. Journal of computational neuroscience. 27 [PubMed]

Szűcs A, Rátkai A, Schlett K, Huerta R. (2017). Frequency-dependent regulation of intrinsic excitability by voltage-activated membrane conductances, computational modeling and dynamic clamp. The European journal of neuroscience. 46 [PubMed]

Yu Y, Shu Y, McCormick DA. (2008). Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Zeldenrust F, Chameau PJ, Wadman WJ. (2013). Reliability of spike and burst firing in thalamocortical relay cells. Journal of computational neuroscience. 35 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.