ModelDB: Models that contain Alcohol Use Disorder

Model Concept: Alcohol Use Disorder

Alcohol abuse is a term that describes the harmful effects that drinking too much alcohol can have on health, relationships, and employment. Alcohol dependence refers to the inability to stop drinking alcohol, even when the patient knows it is causing serious problems. Alcohol use disorder is a term defined in DSM-5 with graded clinical severities that combines Alcohol abuse with Alcohol dependency. In ModelDB, relevant models are tagged with this keyword to help physician scientists find basic science results about the effects of alcohol on neurons.

Alcohol action in a detailed Purkinje neuron model and an efficient simplified model (Forrest 2015)
Alcohol excites Cerebellar Golgi Cells by inhibiting the Na+/K+ ATPase (Botta et al.2010)
Nigral dopaminergic neurons: effects of ethanol on Ih (Migliore et al. 2008)
Signaling pathways In D1R containing striatal spiny projection neurons (Blackwell et al 2018)

Top authors for Alcohol Use Disorder:

Forrest MD (1)
Botta P (1)
de Souza FM (1)
Sangrey T (1)
De Schutter E (1)
Valenzuela CF (1)
Migliore M (1)
Cannia C (1)
Canavier CC (1)
Blackwell KT (1)

Top concepts studied with Alcohol Use Disorder:

Detailed Neuronal Models (3)
Activity Patterns (2)
Bursting (2)
Active Dendrites (2)
Sodium pump (2)
Markov-type model (2)
Dendritic Action Potentials (1)
Ion Channel Kinetics (1)
Oscillations (1)
Simplified Models (1)

Top neurons studied with Alcohol Use Disorder:

Cerebellum Purkinje GABA cell (1)
Cerebellum golgi cell (1)
Substantia nigra pars compacta DA cell (1)
Neostriatum medium spiny direct pathway GABA cell (1)

Top currents studied with Alcohol Use Disorder:

Na/K pump (3)
I Na,t (2)
I A (2)
I K (2)
I K,leak (2)
I h (2)
I Calcium (2)
I T low threshold (1)
I M (1)
I K,Ca (1)

Top references cited by these models:

Brodie MS, Appel SB. (1998). The effects of ethanol on dopaminergic neurons of the ventral tegmental area studied with intracellular recording in brain slices. Alcoholism, clinical and experimental research. 22 (3)
Mereu G, Fadda F, Gessa GL. (1984). Ethanol stimulates the firing rate of nigral dopaminergic neurons in unanesthetized rats. Brain research. 292 (3)
Okamoto T, Harnett MT, Morikawa H. (2006). Hyperpolarization-activated cation current (Ih) is an ethanol target in midbrain dopamine neurons of mice. Journal of neurophysiology. 95 (3)
Hines ML, Carnevale NT. (1997). The NEURON simulation environment. Neural computation. 9 (2)
Genet S, Kado RT. (1997). Hyperpolarizing current of the Na/K ATPase contributes to the membrane polarization of the Purkinje cell in rat cerebellum. Pflugers Archiv : European journal of physiology. 434 (2)