Signaling pathways In D1R containing striatal spiny projection neurons (Blackwell et al 2018)

We implemented a mechanistic model of signaling pathways activated by dopamine D1 receptors, acetylcholine receptors, and glutamate. We use our novel, computationally efficient simulator, NeuroRD, to simulate stochastic interactions both within and between dendritic spines. Results show that the combined activity of several key plasticity molecules correctly predicts the occurrence of either LTP, LTD or no plasticity for numerous experimental protocols.

Model Type: Molecular Network; Synapse

Region(s) or Organism(s): Basal ganglia; Striatum

Cell Type(s): Neostriatum medium spiny direct pathway GABA cell

Receptors: D1; mGluR5; M1; M4

Transmitters: Acetylcholine; Dopamine; Endocannabinoid; Glutamate

Model Concept(s): G-protein coupled; Long-term Synaptic Plasticity; Signaling pathways; Alcohol Use Disorder

Simulation Environment: NeuroRD

Implementer(s): Blackwell, Avrama [avrama at]


Blackwell KT et al. (2019). Molecular mechanisms underlying striatal synaptic plasticity: relevance to chronic alcohol consumption and seeking. The European journal of neuroscience. 49 [PubMed]

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