Clancy CE, Rudy Y. (1999). Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia. Nature. 400 [PubMed]

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References and models cited by this paper

Balser JR, Roden DM, Bennett PB. (1990). Global parameter optimization for cardiac potassium channel gating models. Biophysical journal. 57 [PubMed]

Barinaga M. (1998). Tracking down mutations that can stop the heart. Science (New York, N.Y.). 281 [PubMed]

Bennett PB, Yazawa K, Makita N, George AL. (1995). Molecular mechanism for an inherited cardiac arrhythmia. Nature. 376 [PubMed]

Chandra R, Starmer CF, Grant AO. (1998). Multiple effects of KPQ deletion mutation on gating of human cardiac Na+ channels expressed in mammalian cells. The American journal of physiology. 274 [PubMed]

Dumaine R et al. (1996). Multiple mechanisms of Na+ channel--linked long-QT syndrome. Circulation research. 78 [PubMed]

HODGKIN AL, HUXLEY AF. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. The Journal of physiology. 117 [PubMed]

Hanck DA. (1995). Cardiac Electrophysiology: From Cell To Bedside.

Keating MT, Sanguinetti MC. (1996). Molecular genetic insights into cardiovascular disease. Science (New York, N.Y.). 272 [PubMed]

Kunkel TA, Wilson SH. (1996). DNA repair. Push and pull of base flipping. Nature. 384 [PubMed]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circulation research. 74 [PubMed]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation. Circulation research. 74 [PubMed]

Mitsuiye T, Noma A. (1995). Inactivation of the cardiac Na+ channels in guinea-pig ventricular cells through the open state. The Journal of physiology. 485 ( Pt 3) [PubMed]

Schwartz PJ et al. (1995). Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy. Circulation. 92 [PubMed]

Tomaselli GF et al. (1995). A mutation in the pore of the sodium channel alters gating. Biophysical journal. 68 [PubMed]

Wang DW, Yazawa K, George AL, Bennett PB. (1996). Characterization of human cardiac Na+ channel mutations in the congenital long QT syndrome. Proceedings of the National Academy of Sciences of the United States of America. 93 [PubMed]

Wang DW, Yazawa K, Makita N, George AL, Bennett PB. (1997). Pharmacological targeting of long QT mutant sodium channels. The Journal of clinical investigation. 99 [PubMed]

Welsh MJ, Hoshi T. (1995). Molecular cardiology. Ion channels lose the rhythm. Nature. 376 [PubMed]

Yang XL, Wu SM. (1989). Modulation of rod-cone coupling by light. Science (New York, N.Y.). 244 [PubMed]

Zeng J. (1997). Biomedical Engineering.

Zeng J, Laurita KR, Rosenbaum DS, Rudy Y. (1995). Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. Circulation research. 77 [PubMed]

Zeng J, Rudy Y. (1995). Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence. Biophysical journal. 68 [PubMed]

References and models that cite this paper

Clancy CE, Kass RS. (2004). Theoretical investigation of the neuronal Na+ channel SCN1A: abnormal gating and epilepsy. Biophysical journal. 86 [PubMed]

Clancy CE, Rudy Y. (2001). Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death. Cardiovascular research. 50 [PubMed]

Clancy CE, Rudy Y. (2002). Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism. Circulation. 105 [PubMed]

Dahlem MA, Schumacher J, Hübel N. (2014). Linking a genetic defect in migraine to spreading depression in a computational model. PeerJ. 2 [PubMed]

Faber GM, Rudy Y. (2000). Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study. Biophysical journal. 78 [PubMed]

Iyer V, Mazhari R, Winslow RL. (2004). A computational model of the human left-ventricular epicardial myocyte. Biophysical journal. 87 [PubMed]

Kahlig KM, Misra SN, George AL. (2006). Impaired inactivation gate stabilization predicts increased persistent current for an epilepsy-associated SCN1A mutation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Mahajan A et al. (2008). A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates. Biophysical journal. 94 [PubMed]

Mazhari R, Greenstein JL, Winslow RL, Marbán E, Nuss HB. (2001). Molecular interactions between two long-QT syndrome gene products, HERG and KCNE2, rationalized by in vitro and in silico analysis. Circulation research. 89 [PubMed]

Viswanathan PC, Rudy Y. (2000). Cellular arrhythmogenic effects of congenital and acquired long-QT syndrome in the heterogeneous myocardium. Circulation. 101 [PubMed]

Winslow RL, Greenstein JL. (2004). The ongoing journey to understand heart function through integrative modeling. Circulation research. 95 [PubMed]

Xu J, Clancy CE. (2008). Ionic mechanisms of endogenous bursting in CA3 hippocampal pyramidal neurons: a model study. PloS one. 3 [PubMed]

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