Faber GM, Rudy Y. (2000). Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study. Biophysical journal. 78 [PubMed]

See more from authors: Faber GM · Rudy Y

References and models cited by this paper

Bennett PB, Yazawa K, Makita N, George AL. (1995). Molecular mechanism for an inherited cardiac arrhythmia. Nature. 376 [PubMed]

Berlin JR, Cannell MB, Lederer WJ. (1987). Regulation of twitch tension in sheep cardiac Purkinje fibers during calcium overload. The American journal of physiology. 253 [PubMed]

Bers DM, Christensen DM, Nguyen TX. (1988). Can Ca entry via Na-Ca exchange directly activate cardiac muscle contraction? Journal of molecular and cellular cardiology. 20 [PubMed]

Brill DM, Wasserstrom JA. (1986). Intracellular sodium and the positive inotropic effect of veratridine and cardiac glycoside in sheep Purkinje fibers. Circulation research. 58 [PubMed]

Carl SL et al. (1995). Immunolocalization of sarcolemmal dihydropyridine receptor and sarcoplasmic reticular triadin and ryanodine receptor in rabbit ventricle and atrium. The Journal of cell biology. 129 [PubMed]

Carmeliet E. (1992). A fuzzy subsarcolemmal space for intracellular Na+ in cardiac cells? Cardiovascular research. 26 [PubMed]

Chandra R, Starmer CF, Grant AO. (1998). Multiple effects of KPQ deletion mutation on gating of human cardiac Na+ channels expressed in mammalian cells. The American journal of physiology. 274 [PubMed]

Clancy CE, Rudy Y. (1999). Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia. Nature. 400 [PubMed]

Cohen CJ, Fozzard HA, Sheu SS. (1982). Increase in intracellular sodium ion activity during stimulation in mammalian cardiac muscle. Circulation research. 50 [PubMed]

Cranefield PF, Aronson RS. (1988). Cardiac Arrhythmias: The Role of Triggered Activity and Other Mechanisms.

Dumaine R et al. (1996). Multiple mechanisms of Na+ channel--linked long-QT syndrome. Circulation research. 78 [PubMed]

Ellis D. (1977). The effects of external cations and ouabain on the intracellular sodium activity of sheep heart Purkinje fibres. The Journal of physiology. 273 [PubMed]

Ferrier GR, Howlett SE. (1995). Contractions in guinea-pig ventricular myocytes triggered by a calcium-release mechanism separate from Na+ and L-currents. The Journal of physiology. 484 ( Pt 1) [PubMed]

Frank JS, Mottino G, Reid D, Molday RS, Philipson KD. (1992). Distribution of the Na(+)-Ca2+ exchange protein in mammalian cardiac myocytes: an immunofluorescence and immunocolloidal gold-labeling study. The Journal of cell biology. 117 [PubMed]

Gao T et al. (1997). Identification and subcellular localization of the subunits of L-type calcium channels and adenylyl cyclase in cardiac myocytes. The Journal of biological chemistry. 272 [PubMed]

Haigney MC, Lakatta EG, Stern MD, Silverman HS. (1994). Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading. Circulation. 90 [PubMed]

Harrison SM, McCall E, Boyett MR. (1992). The relationship between contraction and intracellular sodium in rat and guinea-pig ventricular myocytes. The Journal of physiology. 449 [PubMed]

Hess P, Wier WG. (1984). Excitation-contraction coupling in cardiac Purkinje fibers. Effects of cardiotonic steroids on the intracellular [Ca2+] transient, membrane potential, and contraction. J Gen Physiol. 83

Irisawa H, Sato R. (1986). Intra- and extracellular actions of proton on the calcium current of isolated guinea pig ventricular cells. Circulation research. 59 [PubMed]

Kameyama M et al. (1984). Intracellular Na+ activates a K+ channel in mammalian cardiac cells. Nature. 309 [PubMed]

Karmazyn M. (1996). The sodium-hydrogen exchange system in the heart: its role in ischemic and reperfusion injury and therapeutic implications. The Canadian journal of cardiology. 12 [PubMed]

Kieval RS, Bloch RJ, Lindenmayer GE, Ambesi A, Lederer WJ. (1992). Immunofluorescence localization of the Na-Ca exchanger in heart cells. The American journal of physiology. 263 [PubMed]

Kohomoto O, Levi AJ, Bridge JH. (1994). Relation between reverse sodium-calcium exchange and sarcoplasmic reticulum calcium release in guinea pig ventricular cells. Circulation research. 74 [PubMed]

Leblanc N, Hume JR. (1990). Sodium current-induced release of calcium from cardiac sarcoplasmic reticulum. Science (New York, N.Y.). 248 [PubMed]

Levesque PC, Leblanc N, Hume JR. (1994). Release of calcium from guinea pig cardiac sarcoplasmic reticulum induced by sodium-calcium exchange. Cardiovascular research. 28 [PubMed]

Levi AJ. (1991). The effect of strophanthidin on action potential, calcium current and contraction in isolated guinea-pig ventricular myocytes. The Journal of physiology. 443 [PubMed]

Levi AJ. (1993). A role for sodium/calcium exchange in the action potential shortening caused by strophanthidin in guinea pig ventricular myocytes. Cardiovascular research. 27 [PubMed]

Levi AJ et al. (1997). Role of intracellular sodium overload in the genesis of cardiac arrhythmias. Journal of cardiovascular electrophysiology. 8 [PubMed]

Levi AJ, Spitzer KW, Kohmoto O, Bridge JH. (1994). Depolarization-induced Ca entry via Na-Ca exchange triggers SR release in guinea pig cardiac myocytes. The American journal of physiology. 266 [PubMed]

Litwin S, Kohmoto O, Levi AJ, Spitzer KW, Bridge JH. (1996). Evidence that reverse Na-Ca exchange can trigger SR calcium release. Annals of the New York Academy of Sciences. 779 [PubMed]

Litwin SE, Bridge JH. (1997). Enhanced Na(+)-Ca2+ exchange in the infarcted heart. Implications for excitation-contraction coupling. Circulation research. 81 [PubMed]

Litwin SE, Li J, Bridge JH. (1998). Na-Ca exchange and the trigger for sarcoplasmic reticulum Ca release: studies in adult rabbit ventricular myocytes. Biophysical journal. 75 [PubMed]

Lu HR, De Clerck F. (1993). R 56 865, a Na+/Ca(2+)-overload inhibitor, protects against aconitine-induced cardiac arrhythmias in vivo. Journal of cardiovascular pharmacology. 22 [PubMed]

Luk HN, Carmeliet E. (1990). Na(+)-activated K+ current in cardiac cells: rectification, open probability, block and role in digitalis toxicity. Pflugers Archiv : European journal of physiology. 416 [PubMed]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circulation research. 74 [PubMed]

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation. Circulation research. 74 [PubMed]

Matsuoka S, Hilgemann DW. (1992). Steady-state and dynamic properties of cardiac sodium-calcium exchange. Ion and voltage dependencies of the transport cycle. The Journal of general physiology. 100 [PubMed]

Nagatomo T et al. (1998). Temperature dependence of early and late currents in human cardiac wild-type and long Q-T DeltaKPQ Na+ channels. The American journal of physiology. 275 [PubMed]

Nakao M, Gadsby DC. (1989). [Na] and [K] dependence of the Na/K pump current-voltage relationship in guinea pig ventricular myocytes. The Journal of general physiology. 94 [PubMed]

Nuss HB, Houser SR. (1992). Sodium-calcium exchange-mediated contractions in feline ventricular myocytes. The American journal of physiology. 263 [PubMed]

Radford NB, Makos JD, Ramasamy R, Sherry AD, Malloy CR. (1998). Dissociation of intracellular sodium from contractile state in guinea-pig hearts treated with ouabain. Journal of molecular and cellular cardiology. 30 [PubMed]

Ravens U, Himmel HM. (1999). Drugs preventing Na+ and Ca2+ overload. Pharmacological research. 39 [PubMed]

Sanguinetti MC. (1990). Na+-activated and ATP-sensitive K+ channels in the heart Potassium Channels: Basic Function and Therapeutic Aspects.

Shaw RM, Rudy Y. (1997). Electrophysiologic effects of acute myocardial ischemia: a theoretical study of altered cell excitability and action potential duration. Cardiovascular research. 35 [PubMed]

Sipido KR, Maes M, Van de Werf F. (1997). Low efficiency of Ca2+ entry through the Na(+)-Ca2+ exchanger as trigger for Ca2+ release from the sarcoplasmic reticulum. A comparison between L-type Ca2+ current and reverse-mode Na(+)-Ca2+ exchange. Circulation research. 81 [PubMed]

Smith TW, Antman EM, Friedman PL, Blatt CM, Marsh JD. (1984). Digitalis glycosides: mechanisms and manifestations of toxicity. Part I. Progress in cardiovascular diseases. 26 [PubMed]

Tani M, Neely JR. (1990). Na+ accumulation increases Ca2+ overload and impairs function in anoxic rat heart. Journal of molecular and cellular cardiology. 22 [PubMed]

Varghese A, Sell GR. (1997). A conservation principle and its effect on the formulation of Na-Ca exchanger current in cardiac cells. Journal of theoretical biology. 189 [PubMed]

Veldkamp MW, Vereecke J, Carmeliet E. (1994). Effects of intracellular sodium and hydrogen ion on the sodium activated potassium channel in isolated patches from guinea pig ventricular myocytes. Cardiovascular research. 28 [PubMed]

Viswanathan PC, Shaw RM, Rudy Y. (1999). Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study. Circulation. 99 [PubMed]

Vornanen M, Shepherd N, Isenberg G. (1994). Tension-voltage relations of single myocytes reflect Ca release triggered by Na/Ca exchange at 35 degrees C but not 23 degrees C. The American journal of physiology. 267 [PubMed]

Wang DY, Chae SW, Gong QY, Lee CO. (1988). Role of aiNa in positive force-frequency staircase in guinea pig papillary muscle. The American journal of physiology. 255 [PubMed]

Wang Z, Kimitsuki T, Noma A. (1991). Conductance properties of the Na(+)-activated K+ channel in guinea-pig ventricular cells. The Journal of physiology. 433 [PubMed]

Wasserstrom JA, Vites AM. (1999). Activation of contraction in cat ventricular myocytes: effects of low Cd(2+) concentration and temperature. The American journal of physiology. 277 [PubMed]

Wendt-Gallitelli MF, Voigt T, Isenberg G. (1993). Microheterogeneity of subsarcolemmal sodium gradients. Electron probe microanalysis in guinea-pig ventricular myocytes. The Journal of physiology. 472 [PubMed]

Zeng J, Laurita KR, Rosenbaum DS, Rudy Y. (1995). Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. Circulation research. 77 [PubMed]

Zeng J, Rudy Y. (1995). Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence. Biophysical journal. 68 [PubMed]

van Echteld CJ, Kirkels JH, Eijgelshoven MH, van der Meer P, Ruigrok TJ. (1991). Intracellular sodium during ischemia and calcium-free perfusion: a 23Na NMR study. Journal of molecular and cellular cardiology. 23 [PubMed]

References and models that cite this paper

Clancy CE, Rudy Y. (2001). Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death. Cardiovascular research. 50 [PubMed]

Flaim SN, Giles WR, McCulloch AD. (2006). Contributions of sustained INa and IKv43 to transmural heterogeneity of early repolarization and arrhythmogenesis in canine left ventricular myocytes. American journal of physiology. Heart and circulatory physiology. 291 [PubMed]

Greenstein JL, Hinch R, Winslow RL. (2006). Mechanisms of excitation-contraction coupling in an integrative model of the cardiac ventricular myocyte. Biophysical journal. 90 [PubMed]

Greenstein JL, Winslow RL. (2002). An integrative model of the cardiac ventricular myocyte incorporating local control of Ca2+ release. Biophysical journal. 83 [PubMed]

Gurkiewicz M, Korngreen A, Waxman SG, Lampert A. (2011). Kinetic modeling of Nav1.7 provides insight into erythromelalgia-associated F1449V mutation. Journal of neurophysiology. 105 [PubMed]

Hinch R, Greenstein JL, Tanskanen AJ, Xu L, Winslow RL. (2004). A simplified local control model of calcium-induced calcium release in cardiac ventricular myocytes. Biophysical journal. 87 [PubMed]

Iyer V, Mazhari R, Winslow RL. (2004). A computational model of the human left-ventricular epicardial myocyte. Biophysical journal. 87 [PubMed]

Severi S, Corsi C, Rocchetti M, Zaza A. (2009). Mechanisms of beta-adrenergic modulation of I(Ks) in the guinea-pig ventricle: insights from experimental and model-based analysis. Biophysical journal. 96 [PubMed]

Sung RJ, Wu SN, Wu JS, Chang HD, Luo CH. (2006). Electrophysiological mechanisms of ventricular arrhythmias in relation to Andersen-Tawil syndrome under conditions of reduced IK1: a simulation study. American journal of physiology. Heart and circulatory physiology. 291 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.