ModelDB: Models that contain Timothy Syndrome

Model Concept: Timothy Syndrome

A disease caused by a spontaneous mutation in the Cav1.2 channel gene. The patients have irregular heart beats and webbing (skin between) the fingers and toes, intermitent low blood sugar, autism, and immune system depression.

Ionic basis of alternans and Timothy Syndrome (Fox et al. 2002), (Zhu and Clancy 2007)

Top authors for Timothy Syndrome:

Fox JJ (1)
McHarg JL (1)
Gilmour RF (1)
Zhu ZI (1)
Clancy CE (1)

Top concepts studied with Timothy Syndrome:

Temporal Pattern Generation (1)
Heart disease (1)
Long-QT (1)
Sodium pump (1)

Top currents studied with Timothy Syndrome:

I Na,t (1)
I L high threshold (1)
I Calcium (1)
I Potassium (1)
Na/Ca exchanger (1)
I_Ks (1)
Na/K pump (1)

Top references cited by these models:

Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circulation research. 74 (2)
Luo CH, Rudy Y. (1991). A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction. Circulation research. 68 (2)
Nolasco JB, Dahlen RW. (1968). A graphic method for the study of alternation in cardiac action potentials. Journal of applied physiology. 25 (2)
Karma A. (1994). Electrical alternans and spiral wave breakup in cardiac tissue. Chaos (Woodbury, N.Y.). 4 (2)
Koller ML, Riccio ML, Gilmour RF. (1998). Dynamic restitution of action potential duration during electrical alternans and ventricular fibrillation. The American journal of physiology. 275 (2)

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