ModelDB: Models that contain Nociception

Model Concept: Nociception

The physiology associated with transmission of pain information to the brain. The pathway in humans involves NaV1.7 channels and P2 receptors on "A delta" and "C" peripheral nerve fibers.

A model for a nociceptor terminal and terminal tree (Barkai et al., 2020)
Cold-Temperature Coding with Bursting and Spiking Based on TRP Channel Dynamics in Drosophila Larva Sensory Neurons (Maksymchuk, N., A. Sakurai, D.N. Cox, and G.S. Cymbalyuk, 2023)
Computational model of bladder small DRG neuron soma (Mandge & Manchanda 2018)
Dorsal root ganglion (primary somatosensory) neurons (Rho & Prescott 2012)
DRG nociceptors from wild-type and Fhf2-KO mice. Fhf2 gene knockout blocks heat nociception. (Marra et al., 2023)
Experimental and modeling studies of desensitization of P2X3 receptors (Sokolova et al. 2006)
Explaining pathological changes in axonal excitability by dynamical analysis (Coggan et al. 2011)
HMM of Nav1.7 WT and F1449V (Gurkiewicz et al. 2011)
Kinetics of the P2X7 receptor as expressed in Xenopus oocytes (Riedel et al. 2007a,b)
Modeling a Nociceptive Neuro-Immune Synapse Activated by ATP and 5-HT in Meninges (Suleimanova et al., 2020)
Models of Na channels from a paper on the PKC control of I Na,P (Baker 2005)
Tonic neuron in spinal lamina I: prolongation of subthreshold depol. (Prescott and De Koninck 2005)
Transient and Steady-State Properties of Drosophila Sensory Neurons Coding Noxious Cold Temperature; (Maksymchuk, N., Sakurai, A., Cox, D. N., & Cymbalyuk, G. 2022)
TTX-R Na+ current effect on cell response (Herzog et al 2001)
TTX-R Na+ current effect on cell response (Herzog et al 2001) (MATLAB)

Top authors for Nociception:

Top concepts studied with Nociception:

Top neurons studied with Nociception:

Dorsal Root Ganglion (DRG) cell (6)
Urinary Bladder small-diameter DRG neuron (1)
Abstract Morris-Lecar neuron (1)
Microglia (1)
Macrophage (1)
B lymphocyte (1)
Spinal cord lamina I neuron (1)

Top currents studied with Nociception:

I Na,p (5)
I Sodium (4)
I Na,t (4)
I Calcium (3)
I h (3)
I K (3)
I Potassium (2)
I trp (2)
I K,Ca (2)
I Na, slow inactivation (1)

Top references cited by these models: