Computational neuropharmacology of CA1 pyramidal neuron (Ferrante et al. 2008)

In this paper, the model was used to show how neuroactive drugs targeting different neuronal mechanisms affect the signal integration in CA1 pyramidal neuron. Ferrante M, Blackwell KT, Migliore M, Ascoli GA (2008)

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Hippocampus

Cell Type(s): Hippocampus CA1 pyramidal GLU cell

Currents: I Na,t; I A; I K; I h

Transmitters: Gaba; Glutamate

Model Concept(s): Action Potential Initiation; Action Potentials; Pathophysiology; Epilepsy; Synaptic Integration; Parkinson's; Aging/Alzheimer`s; Schizophrenia; Spike Frequency Adaptation

Simulation Environment: NEURON

Implementer(s): Ferrante, Michele [mferr133 at bu.edu]

References:

Ferrante M, Blackwell KT, Migliore M, Ascoli GA. (2008). Computational models of neuronal biophysics and the characterization of potential neuropharmacological targets. Current medicinal chemistry. 15 [PubMed]