Computer model of clonazepam's effect in thalamic slice (Lytton 1997)

Demonstration of the effect of a minor pharmacological synaptic change at the network level. Clonazepam, a benzodiazepine, enhances inhibition but is paradoxically useful for certain types of seizures. This simulation shows how inhibition of inhibitory cells (the RE cells) produces this counter-intuitive effect.

Model Type: Realistic Network

Region(s) or Organism(s): Thalamus

Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell; Thalamus reticular nucleus GABA cell

Currents: I Na,t; I T low threshold; I K; I CAN

Receptors: GabaA; Gaba

Transmitters: Gaba

Model Concept(s): Activity Patterns; Bursting; Therapeutics; Epilepsy; Calcium dynamics

Simulation Environment: NEURON

Implementer(s): Lytton, William [bill.lytton at]


Lytton WW. (1997). Computer model of clonazepam's effect in thalamic slice. Neuroreport 8 [PubMed]