Global structure, robustness, and modulation of neuronal models (Goldman et al. 2001)

"The electrical characteristics of many neurons are remarkably robust in the face of changing internal and external conditions. At the same time, neurons can be highly sensitive to neuromodulators. We find correlates of this dual robustness and sensitivity in a global analysis of the structure of a conductance-based model neuron. ..."

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Stomatogastric ganglion

Currents: I Na,t; I L high threshold; I T low threshold; I A; I K; I K,Ca; I Potassium

Model Concept(s): Bursting; Temporal Pattern Generation; Phase Response Curves

Simulation Environment: C or C++ program

Implementer(s): Goldman, Mark [msgoldman at ucdavis.edu]

References:

Goldman MS, Golowasch J, Marder E, Abbott LF. (2001). Global structure, robustness, and modulation of neuronal models. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21 [PubMed]