Large scale model of the olfactory bulb (Yu et al., 2013)

The readme file currently contains links to the results for all the 72 odors investigated in the paper, and the movie showing the network activity during learning of odor k3-3 (an aliphatic ketone).

Model Type: Realistic Network; Channel/Receptor; Dendrite

Region(s) or Organism(s): Olfactory bulb

Cell Type(s): Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell

Currents: I Na,t; I A; I K

Receptors: NMDA; Glutamate; Gaba

Transmitters: Gaba; Glutamate

Model Concept(s): Pattern Recognition; Activity Patterns; Bursting; Temporal Pattern Generation; Oscillations; Synchronization; Active Dendrites; Detailed Neuronal Models; Synaptic Plasticity; Action Potentials; Synaptic Integration; Unsupervised Learning; Olfaction

Simulation Environment: NEURON

Implementer(s): Hines, Michael [Michael.Hines at Yale.edu]; Migliore, Michele [Michele.Migliore at Yale.edu]

References:

Yu Y et al. (2013). Sparse distributed representation of odors in a large-scale olfactory bulb circuit. PLoS computational biology. 9 [PubMed]