Calcium waves and mGluR-dependent synaptic plasticity in CA1 pyr. neurons (Ashhad & Narayanan 2013)

A morphologically realistic, conductance-based model equipped with kinetic schemes that govern several calcium signalling modules and pathways in CA1 pyramidal neurons

Model Type: Neuron or other electrically excitable cell; Synapse; Channel/Receptor; Dendrite

Region(s) or Organism(s): Hippocampus

Cell Type(s): Hippocampus CA1 pyramidal GLU cell

Currents: I Na,t; I L high threshold; I T low threshold; I A; I K; Ca pump

Receptors: AMPA; NMDA; mGluR; IP3

Transmitters: Glutamate

Model Concept(s): Active Dendrites; Synaptic Plasticity; Signaling pathways; Calcium dynamics; G-protein coupled; Calcium waves

Simulation Environment: NEURON

Implementer(s): Narayanan, Rishikesh [rishi at]; Ashhad, Sufyan [soofy at]


Ashhad S, Narayanan R. (2013). Quantitative interactions between the A-type K+ current and inositol trisphosphate receptors regulate intraneuronal Ca2+ waves and synaptic plasticity. The Journal of physiology 591 [PubMed]