A morphologically realistic, conductance-based model equipped with kinetic schemes that govern several calcium signalling modules and pathways in CA1 pyramidal neurons
Model Type: Neuron or other electrically excitable cell; Synapse; Channel/Receptor; Dendrite
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Currents: I Na,t; I L high threshold; I T low threshold; I A; I K; Ca pump
Receptors: AMPA; NMDA; mGluR; IP3
Transmitters: Glutamate
Model Concept(s): Active Dendrites; Synaptic Plasticity; Signaling pathways; Calcium dynamics; G-protein coupled; Calcium waves
Simulation Environment: NEURON
Implementer(s): Narayanan, Rishikesh [rishi at iisc.ac.in]; Ashhad, Sufyan [soofy at mbu.iisc.ernet.in]
References:
Ashhad S, Narayanan R. (2013). Quantitative interactions between the A-type K+ current and inositol trisphosphate receptors regulate intraneuronal Ca2+ waves and synaptic plasticity. The Journal of physiology. 591 [PubMed]