L5 PFC microcircuit used to study persistent activity (Papoutsi et al. 2014, 2013)

Using a heavily constrained biophysical model of a L5 PFC microcircuit we investigate the mechanisms that underlie persistent activity emergence (ON) and termination (OFF) and search for the minimum network size required for expressing these states within physiological regimes.

Model Type: Dendrite; Connectionist Network

Region(s) or Organism(s): Neocortex

Cell Type(s): Neocortex L5/6 pyramidal GLU cell

Currents: I Na,p; I Na,t; I L high threshold; I A; I CAN; I Potassium; I R; I_AHP

Receptors: GabaA; GabaB; AMPA; NMDA

Model Concept(s): Active Dendrites; Working memory

Simulation Environment: NEURON

Implementer(s): Papoutsi, Athanasia [athpapoutsi at gmail.com]


Papoutsi A, Sidiropoulou K, Cutsuridis V, Poirazi P. (2013). Induction and modulation of persistent activity in a layer V PFC microcircuit model. Frontiers in neural circuits 7 [PubMed]

Papoutsi A, Sidiropoulou K, Poirazi P. (2014). Dendritic nonlinearities reduce network size requirements and mediate ON and OFF states of persistent activity in a PFC microcircuit model. PLoS computational biology 10 [PubMed]