Using a heavily constrained biophysical model of a L5 PFC microcircuit we investigate the mechanisms that underlie persistent activity emergence (ON) and termination (OFF) and search for the minimum network size required for expressing these states within physiological regimes.
Model Type: Dendrite; Connectionist Network
Region(s) or Organism(s): Neocortex
Cell Type(s): Neocortex L5/6 pyramidal GLU cell
Currents: I Na,p; I Na,t; I L high threshold; I A; I CAN; I Potassium; I R; I_AHP
Receptors: GabaA; GabaB; AMPA; NMDA
Model Concept(s): Active Dendrites; Working memory
Simulation Environment: NEURON
Implementer(s): Papoutsi, Athanasia [athpapoutsi at gmail.com]
References:
Papoutsi A, Sidiropoulou K, Cutsuridis V, Poirazi P. (2013). Induction and modulation of persistent activity in a layer V PFC microcircuit model. Frontiers in neural circuits 7 [PubMed]
Papoutsi A, Sidiropoulou K, Poirazi P. (2014). Dendritic nonlinearities reduce network size requirements and mediate ON and OFF states of persistent activity in a PFC microcircuit model. PLoS computational biology 10 [PubMed]