A component of recorded currents demonstrated kinetics consistent with a current originating at a site spatially segregated from the soma. In response to step commands this component was seen as a late-onset, low amplitude persistent current whilst in response to depolarizing-repolarizing ramp commands a low voltage clockwise current hysteresis was recorded. Simulations using a neuromorphic motoneuron model could reproduce these currents only if a noninactivating calcium conductance was placed in the dendritic compartments.
Model Type: Neuron or other electrically excitable cell
Currents: I L high threshold; I N; I Calcium
Model Concept(s): Bursting; Ion Channel Kinetics; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Dendritic Bistability
Simulation Environment: NEURON
Implementer(s): Jones, Kelvin E [KEJones at ualberta.ca]
References:
Carlin KP, Jones KE, Jiang Z, Jordan LM, Brownstone RM. (2000). Dendritic L-type calcium currents in mouse spinal motoneurons: implications for bistability. The European journal of neuroscience. 12 [PubMed]