This is a model of the cortex of (Benita et al., 2012), the thalamus of (Soplata et al., 2017), and simple AMPAergic thalamocortical and corticothalamic connections between them, built using the Matlab-based Dynasim simulator. We used this to investigate how slow wave and alpha oscillations interact under propofol anesthesia, including neuromodulatory changes.
Model Type: Realistic Network
Region(s) or Organism(s): Thalamus; Neocortex
Cell Type(s): Hodgkin-Huxley neuron; Thalamus reticular nucleus GABA cell
Currents: Ca pump; I_K,Na; I h; I T low threshold; I Calcium; I Na, leak; I Na,t; I K; I K,leak
Receptors: AMPA; NMDA; GabaA; GabaB; Cholinergic Receptors; Muscarinic
Transmitters: Gaba; Glutamate; Acetylcholine
Model Concept(s): Activity Patterns; Oscillations; Sleep; Synchronization
Simulation Environment: Network
Implementer(s): Soplata, Austin E
References:
Soplata AE et al. (2023). Rapid thalamocortical network switching mediated by cortical synchronization underlies propofol-induced EEG signatures: a biophysical model. Journal of neurophysiology. 130 [PubMed]