"Despite advances in experimental techniques and accumulation of large datasets concerning the composition and properties of the cortex, quantitative modeling of cortical circuits under in-vivo-like conditions remains challenging. Here we report and publicly release a biophysically detailed circuit model of layer 4 in the mouse primary visual cortex, receiving thalamo- cortical visual inputs. The 45,000-neuron model was subjected to a battery of visual stimuli, and results were compared to published work and new in vivo experiments. ..."
Model Type: Realistic Network; Neuron or other electrically excitable cell
Region(s) or Organism(s): Neocortex
Cell Type(s): Neocortex V1 interneuron chandelier SOM GABA cell; Neocortex V1 interneuron basket PV GABA cell; Neocortex layer 4 pyramidal cell
Currents: I L high threshold; I T low threshold; I M; I Krp; I K; I Na,p; I Na,t; IK Skca
Model Concept(s): Simplified Models; Detailed Neuronal Models; Brain Rhythms; Gamma oscillations; Triggered activity; Activity Patterns; Orientation selectivity
Simulation Environment: NEURON (web link to model); BioNet (web link to model)
Arkhipov A et al. (2018). Visual physiology of the layer 4 cortical circuit in silico. PLoS computational biology 14 [PubMed]