See README file for all info on how to run models under different tasks and simulated Parkinson's and medication conditions.
Model Type: Realistic Network
Region(s) or Organism(s): Basal ganglia
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell
Currents: I Na,t; I K,leak; I Cl,Ca
Receptors: D1; D2; Glutamate; Gaba
Transmitters: Dopamine; Gaba; Glutamate
Model Concept(s): Simplified Models; Synaptic Plasticity; Pathophysiology; Rate-coding model neurons; Parkinson's; Reinforcement Learning; Action Selection/Decision Making; Hebbian plasticity
Simulation Environment: Emergent/PDP++
Implementer(s): Frank, Michael [mfrank at u.arizona.edu]
References:
Frank MJ. (2005). Dynamic dopamine modulation in the basal ganglia: a neurocomputational account of cognitive deficits in medicated and nonmedicated Parkinsonism. Journal of cognitive neuroscience 17 [PubMed]
Frank MJ, Seeberger LC, O'reilly RC. (2004). By carrot or by stick: cognitive reinforcement learning in parkinsonism. Science (New York, N.Y.) 306 [PubMed]