Dynamic dopamine modulation in the basal ganglia: Learning in Parkinson (Frank et al 2004,2005)

See README file for all info on how to run models under different tasks and simulated Parkinson's and medication conditions.

Model Type: Realistic Network

Region(s) or Organism(s): Basal ganglia

Cell Type(s): Neostriatum medium spiny direct pathway GABA cell

Currents: I Na,t; I K,leak; I Cl,Ca

Receptors: D1; D2; Glutamate; Gaba

Transmitters: Dopamine; Gaba; Glutamate

Model Concept(s): Simplified Models; Synaptic Plasticity; Pathophysiology; Rate-coding model neurons; Parkinson's; Reinforcement Learning; Action Selection/Decision Making; Hebbian plasticity

Simulation Environment: Emergent/PDP++

Implementer(s): Frank, Michael [mfrank at u.arizona.edu]


Frank MJ. (2005). Dynamic dopamine modulation in the basal ganglia: a neurocomputational account of cognitive deficits in medicated and nonmedicated Parkinsonism. Journal of cognitive neuroscience 17 [PubMed]

Frank MJ, Seeberger LC, O'reilly RC. (2004). By carrot or by stick: cognitive reinforcement learning in parkinsonism. Science (New York, N.Y.) 306 [PubMed]