Spiking neuron model of the basal ganglia (Humphries et al 2006)


A spiking neuron model of the basal ganglia (BG) circuit (striatum, STN, GP, SNr). Includes: parallel anatomical channels; tonic dopamine; dopamine receptors in striatum, STN, and GP; burst-firing in STN; GABAa, AMPA, and NMDA currents; effects of synaptic location. Model demonstrates selection and switching of input signals. Replicates experimental data on changes in slow-wave (<1 Hz) and gamma-band oscillations within BG nuclei following lesions and pharmacological manipulations.

Model Type: Realistic Network

Region(s) or Organism(s): Basal ganglia

Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Subthalamus nucleus projection neuron; Globus pallidus neuron; Abstract integrate-and-fire leaky neuron

Receptors: Dopaminergic Receptor

Transmitters: Dopamine; Gaba; Glutamate

Model Concept(s): Oscillations; Parkinson's; Action Selection/Decision Making; Sleep; Rebound firing

Simulation Environment: MATLAB

Implementer(s): Humphries, Mark D [m.d.humphries at shef.ac.uk]

References:

Humphries MD, Stewart RD, Gurney KN. (2006). A physiologically plausible model of action selection and oscillatory activity in the basal ganglia. The Journal of neuroscience : the official journal of the Society for Neuroscience 26 [PubMed]