Studies of stimulus parameters for seizure disruption using NN simulations (Anderson et al. 2007)

Architecturally realistic neocortical model using seven classes of excitatory and inhibitory single compartment Hodgkin-Huxley cells. Wiring is adapted to minicolumn hypothesis and incorporates visual and neocortical data. Simulation demonstrates spontaneous bursting onset and cessation, and activity can be altered with external electric field.

Model Type: Realistic Network

Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell; Neocortex V1 interneuron basket PV GABA cell; Neocortex fast spiking (FS) interneuron

Currents: I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium

Receptors: AMPA; Gaba

Model Concept(s): Bursting; Epilepsy; Vision

Simulation Environment: C or C++ program

References:

Anderson WS, Kudela P, Cho J, Bergey GK, Franaszczuk PJ. (2007). Studies of stimulus parameters for seizure disruption using neural network simulations. Biological cybernetics. 97 [PubMed]