Tonic-clonic transitions in a seizure simulation (Lytton and Omurtag 2007)

Bush PC, Prince DA, Miller KD. (1999). Increased pyramidal excitability and NMDA conductance can explain posttraumatic epileptogenesis without disinhibition: a model. Journal of neurophysiology. 82 [PubMed]

• Cortical network model of posttraumatic epileptogenesis (Bush et al 1999) [Model]

Dudek FE, Patrylo PR, Wuarin JP. (1999). Mechanisms of neuronal synchronization during epileptiform activity. Advances in neurology. 79 [PubMed]

Garcia Dominguez L et al. (2005). Enhanced synchrony in epileptiform activity? Local versus distant phase synchronization in generalized seizures. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]

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Lytton WW. (2002). From Computer To Brain.

Lytton WW. (2006). Neural Query System: Data-mining from within the NEURON simulator. Neuroinformatics. 4 [PubMed]

• Neural Query System NQS Data-Mining From Within the NEURON Simulator (Lytton 2006) [Model]

Lytton WW, Hellman KM, Sutula TP. (1998). Computer models of hippocampal circuit changes of the kindling model of epilepsy. Artificial intelligence in medicine. 13 [PubMed]

Lytton WW, Sejnowski TJ. (1991). Simulations of cortical pyramidal neurons synchronized by inhibitory interneurons. Journal of neurophysiology. 66 [PubMed]

Lytton WW, Stewart M. (2005). A rule-based firing model for neural networks Int J Bioelectromagn. 7

Lytton WW, Stewart M. (2006). Rule-based firing for network simulations. Neurocomputing. 69

Meeren HK, Pijn JP, Van Luijtelaar EL, Coenen AM, Lopes da Silva FH. (2002). Cortical focus drives widespread corticothalamic networks during spontaneous absence seizures in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]

Migliore M, Cannia C, Lytton WW, Markram H, Hines ML. (2006). Parallel network simulations with NEURON. Journal of computational neuroscience. 21 [PubMed]

• Parallel network simulations with NEURON (Migliore et al 2006) [Model]

Omurtag A, Knight BW, Sirovich L. (2000). On the simulation of large populations of neurons. Journal of computational neuroscience. 8 [PubMed]

Sirovich L, Omurtag A, Lubliner K. (2006). Dynamics of neural populations: stability and synchrony. Network (Bristol, England). 17 [PubMed]

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Van Drongelen W, Koch H, Marcuccilli C, Pena F, Ramirez JM. (2003). Synchrony levels during evoked seizure-like bursts in mouse neocortical slices. Journal of neurophysiology. 90 [PubMed]

Xie X, Lancaster B, Peakman T, Garthwaite J. (1995). Interaction of the antiepileptic drug lamotrigine with recombinant rat brain type IIA Na+ channels and with native Na+ channels in rat hippocampal neurones. Pflugers Archiv : European journal of physiology. 430 [PubMed]

van Drongelen W et al. (2005). Emergent epileptiform activity in neural networks with weak excitatory synapses. IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society. 13 [PubMed]

Chadderdon GL et al. (2014). Motor cortex microcircuit simulation based on brain activity mapping. Neural computation. 26 [PubMed]

• Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014) [Model]

Chadderdon GL, Neymotin SA, Kerr CC, Lytton WW. (2012). Reinforcement learning of targeted movement in a spiking neuronal model of motor cortex. PloS one. 7 [PubMed]

• Reinforcement learning of targeted movement (Chadderdon et al. 2012) [Model]

Dura-Bernal S et al. (2015). Cortical Spiking Network Interfaced with Virtual Musculoskeletal Arm and Robotic Arm. Frontiers in neurorobotics. 9 [PubMed]

• Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015) [Model]

Kerr CC et al. (2012). Electrostimulation as a prosthesis for repair of information flow in a computer model of neocortex. IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society. 20 [PubMed]

• Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012) [Model]

Kerr CC et al. (2013). Cortical information flow in Parkinson's disease: a composite network/field model. Frontiers in computational neuroscience. 7 [PubMed]

• Composite spiking network/neural field model of Parkinsons (Kerr et al 2013) [Model]

Lytton WW, Neymotin SA, Hines ML. (2008). The virtual slice setup. Journal of neuroscience methods. 171 [PubMed]

• The virtual slice setup (Lytton et al. 2008) [Model]

Lytton WW, Neymotin SA, Wester JC, Contreras D. (2011). Neocortical simulation for epilepsy surgery guidance: Localization and intervention Computational Surgery and Dual Training.

• Computational Surgery (Lytton et al. 2011) [Model]

Lytton WW, Omurtag A, Neymotin SA, Hines ML. (2008). Just-in-time connectivity for large spiking networks. Neural computation. 20 [PubMed]

• JitCon: Just in time connectivity for large spiking networks (Lytton et al. 2008) [Model]

Neymotin SA, Chadderdon GL, Kerr CC, Francis JT, Lytton WW. (2013). Reinforcement learning of two-joint virtual arm reaching in a computer model of sensorimotor cortex. Neural computation. 25 [PubMed]

• Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013) [Model]

Neymotin SA, Dura-Bernal S, Lakatos P, Sanger TD, Lytton WW. (2016). Multitarget Multiscale Simulation for Pharmacological Treatment of Dystonia in Motor Cortex. Frontiers in pharmacology. 7 [PubMed]

• Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016) [Model]

Neymotin SA, Jacobs KM, Fenton AA, Lytton WW. (2011). Synaptic information transfer in computer models of neocortical columns. Journal of computational neuroscience. 30 [PubMed]

• Synaptic information transfer in computer models of neocortical columns (Neymotin et al. 2010) [Model]

Neymotin SA, Lee H, Park E, Fenton AA, Lytton WW. (2011). Emergence of physiological oscillation frequencies in a computer model of neocortex. Frontiers in computational neuroscience. 5 [PubMed]

• Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011) [Model]

Uhlrich DJ, Neymotin S, Manning KA. (2008). Data mining of time-domain features from neural extracellular field data Applic. of Comput. Intel. in Bioinf. and Biomed.: Current Trends and Open Problems. 151

• NEURON interfaces to MySQL and the SPUD feature extraction algorithm (Neymotin et al. 2008) [Model]