This is a two-layer biophysical olfactory bulb (OB) network model to study cholinergic neuromodulation. Simulations show that nicotinic receptor activation sharpens mitral cell receptive field, while muscarinic receptor activation enhances network synchrony and gamma oscillations. This general model suggests that the roles of nicotinic and muscarinic receptors in OB are both distinct and complementary to one another, together regulating the effects of ascending cholinergic inputs on olfactory bulb transformations.
Model Type: Realistic Network
Cell Type(s): Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron periglomerular GABA cell; Olfactory bulb main interneuron granule MC GABA cell
Currents: I Na,p; I L high threshold; I T low threshold; I A; I M; I h; I K,Ca; I CAN; I Sodium; I Calcium; I Potassium; I_Ks; I Cl, leak; I Ca,p
Receptors: Nicotinic; GabaA; Muscarinic; AMPA; NMDA
Transmitters: Acetylcholine
Model Concept(s): Sensory processing; Sensory coding; Neuromodulation; Olfaction
Simulation Environment: NEURON; MATLAB
Implementer(s): Li, Guoshi [guoshi_li at med.unc.edu]
References:
Li G, Cleland TA. (2013). A two-layer biophysical model of cholinergic neuromodulation in olfactory bulb. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33 [PubMed]