Cerebellar granular layer (Maex and De Schutter 1998)

Circuit model of the granular layer representing a one-dimensional array of single-compartmental granule cells (grcs) and Golgi cells (Gocs). This paper examines the effects of feedback inhibition (grc -> Goc -> grc) versus feedforward inhibition (mossy fibre -> Goc -> grc) on synchronization and oscillatory behaviour.

Model Type: Realistic Network

Region(s) or Organism(s): Cerebellum

Cell Type(s): Cerebellum interneuron granule GLU cell; Cerebellum golgi cell

Currents: I Na,t; I A; I h; I K,Ca; I L high threshold; I_KD

Receptors: AMPA; GabaA; NMDA

Transmitters: Gaba; Glutamate

Model Concept(s): Synchronization; Oscillations

Simulation Environment: GENESIS

Implementer(s): Maex, Reinoud [reinoud at bbf.uia.ac.be]

References:

Maex R, De Schutter E. (1998). Synchronization of golgi and granule cell firing in a detailed network model of the cerebellar granule cell layer. Journal of neurophysiology. 80 [PubMed]