L4 cortical barrel NN model receiving thalamic input during whisking or touch (Gutnisky et al. 2017)

Excitatory neurons in layer 4 (L4) in the barrel cortex respond relatively strongly to touch but not to whisker movement (Yu et al., Nat. Neurosci. 2016). The model explains the mechanism underlying this effect. The network is settled to filter out most stationary inputs. Brief touch input passes through because it takes time until feed-forward inhibition silences excitatory neurons receiving brief and strong thalamic excitation.

Model Type: Realistic Network

Region(s) or Organism(s): Barrel cortex; Mouse

Cell Type(s): Neocortex layer 4 neuron; Abstract Wang-Buzsaki neuron

Currents: I Na,t; I K

Transmitters: Glutamate; Gaba

Model Concept(s): Sensory processing; Touch; Whisking

Simulation Environment: C or C++ program

Implementer(s): Golomb, David [golomb at bgu.ac.il]


Golomb D et al. (2017). Mechanisms underlying a thalamocortical transformation during active tactile sensation PLoS Comput Biol. 13(6)

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