Model of cerebellar parallel fiber-Purkinje cell LTD and LTP (Gallimore et al 2018)


Gallimore AR, Kim T, Tanaka-Yamamoto K, De Schutter E. (2018). Switching On Depression and Potentiation in the Cerebellum. Cell reports. 22 [PubMed]

See more from authors: Gallimore AR · Kim T · Tanaka-Yamamoto K · De Schutter E

References and models cited by this paper

Ajima A, Ito M. (1995). A unique role of protein phosphatases in cerebellar long-term depression. Neuroreport. 6 [PubMed]

Antunes G, De Schutter E. (2012). A stochastic signaling network mediates the probabilistic induction of cerebellar long-term depression. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32 [PubMed]

Bellamy TC, Garthwaite J. (2001). Sub-second kinetics of the nitric oxide receptor, soluble guanylyl cyclase, in intact cerebellar cells. The Journal of biological chemistry. 276 [PubMed]

Belmeguenai A, Hansel C. (2005). A role for protein phosphatases 1, 2A, and 2B in cerebellar long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]

Bouvier G et al. (2016). Burst-Dependent Bidirectional Plasticity in the Cerebellum Is Driven by Presynaptic NMDA Receptors. Cell reports. 15 [PubMed]

Boxall AR, Garthwaite J. (1996). Long-term depression in rat cerebellum requires both NO synthase and NO-sensitive guanylyl cyclase. The European journal of neuroscience. 8 [PubMed]

Bradshaw JM, Kubota Y, Meyer T, Schulman H. (2003). An ultrasensitive Ca2+/calmodulin-dependent protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signaling. Proceedings of the National Academy of Sciences of the United States of America. 100 [PubMed]

Carney ST et al. (2009). Cannabinoid regulation of nitric oxide synthase I (nNOS) in neuronal cells. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 4 [PubMed]

Chadderton P, Margrie TW, Häusser M. (2004). Integration of quanta in cerebellar granule cells during sensory processing. Nature. 428 [PubMed]

Chen C, Thompson RF. (1995). Temporal specificity of long-term depression in parallel fiber--Purkinje synapses in rat cerebellar slice. Learning & memory (Cold Spring Harbor, N.Y.). 2 [PubMed]

Chen S, Augustine GJ, Chadderton P. (2017). Serial processing of kinematic signals by cerebellar circuitry during voluntary whisking. Nature communications. 8 [PubMed]

Chin D, Means AR. (2000). Calmodulin: a prototypical calcium sensor. Trends in cell biology. 10 [PubMed]

Chung HJ, Steinberg JP, Huganir RL, Linden DJ. (2003). Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression. Science (New York, N.Y.). 300 [PubMed]

Ciani E, Virgili M, Contestabile A. (2002). Akt pathway mediates a cGMP-dependent survival role of nitric oxide in cerebellar granule neurones. Journal of neurochemistry. 81 [PubMed]

Coesmans M, Weber JT, De Zeeuw CI, Hansel C. (2004). Bidirectional parallel fiber plasticity in the cerebellum under climbing fiber control. Neuron. 44 [PubMed]

Dimmeler S et al. (1999). Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature. 399 [PubMed]

Doi T, Kuroda S, Michikawa T, Kawato M. (2005). Inositol 1,4,5-trisphosphate-dependent Ca2+ threshold dynamics detect spike timing in cerebellar Purkinje cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]

Eilers J, Augustine GJ, Konnerth A. (1995). Subthreshold synaptic Ca2+ signalling in fine dendrites and spines of cerebellar Purkinje neurons. Nature. 373 [PubMed]

Emi K et al. (2013). Reevaluation of the role of parallel fiber synapses in delay eyeblink conditioning in mice using Cbln1 as a tool. Frontiers in neural circuits. 7 [PubMed]

Finch EA, Tanaka K, Augustine GJ. (2012). Calcium as a trigger for cerebellar long-term synaptic depression. Cerebellum (London, England). 11 [PubMed]

Gallimore AR, Aricescu AR, Yuzaki M, Calinescu R. (2016). A Computational Model for the AMPA Receptor Phosphorylation Master Switch Regulating Cerebellar Long-Term Depression. PLoS computational biology. 12 [PubMed]

Grabarek Z. (2005). Structure of a trapped intermediate of calmodulin: calcium regulation of EF-hand proteins from a new perspective. Journal of molecular biology. 346 [PubMed]

Gómez del Pulgar T, Velasco G, Guzmán M. (2000). The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt. The Biochemical journal. 347 [PubMed]

Hanley JG, Khatri L, Hanson PI, Ziff EB. (2002). NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex. Neuron. 34 [PubMed]

Hansel C et al. (2006). alphaCaMKII Is essential for cerebellar LTD and motor learning. Neuron. 51 [PubMed]

Hashimoto Y, Sharma RK, Soderling TR. (1989). Regulation of Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase by the autophosphorylated form of Ca2+/calmodulin-dependent protein kinase II. The Journal of biological chemistry. 264 [PubMed]

Howlett AC, Blume LC, Dalton GD. (2010). CB(1) cannabinoid receptors and their associated proteins. Current medicinal chemistry. 17 [PubMed]

Huang Y et al. (2005). S-nitrosylation of N-ethylmaleimide sensitive factor mediates surface expression of AMPA receptors. Neuron. 46 [PubMed]

Ito M. (2001). Cerebellar long-term depression: characterization, signal transduction, and functional roles. Physiological reviews. 81 [PubMed]

Ito T, Yamakuchi M, Lowenstein CJ. (2011). Thioredoxin increases exocytosis by denitrosylating N-ethylmaleimide-sensitive factor. The Journal of biological chemistry. 286 [PubMed]

Jain P, Bhalla US. (2009). Signaling logic of activity-triggered dendritic protein synthesis: an mTOR gate but not a feedback switch. PLoS computational biology. 5 [PubMed]

Kakegawa W, Yuzaki M. (2005). A mechanism underlying AMPA receptor trafficking during cerebellar long-term potentiation. Proceedings of the National Academy of Sciences of the United States of America. 102 [PubMed]

Kawaguchi SY, Hirano T. (2013). Gating of long-term depression by Ca2+/calmodulin-dependent protein kinase II through enhanced cGMP signalling in cerebellar Purkinje cells. The Journal of physiology. 591 [PubMed]

Kitagawa Y, Hirano T, Kawaguchi SY. (2009). Prediction and validation of a mechanism to control the threshold for inhibitory synaptic plasticity. Molecular systems biology. 5 [PubMed]

Kohda K et al. (2013). The d2 glutamate receptor gates long-term depression by coordinating interactions between two AMPA receptor phosphorylation sites. Proceedings of the National Academy of Sciences of the United States of America. 110 [PubMed]

Konnerth A, Dreessen J, Augustine GJ. (1992). Brief dendritic calcium signals initiate long-lasting synaptic depression in cerebellar Purkinje cells. Proceedings of the National Academy of Sciences of the United States of America. 89 [PubMed]

Kubota Y, Bower JM. (2001). Transient versus asymptotic dynamics of CaM kinase II: possible roles of phosphatase. Journal of computational neuroscience. 11 [PubMed]

Launey T, Endo S, Sakai R, Harano J, Ito M. (2004). Protein phosphatase 2A inhibition induces cerebellar long-term depression and declustering of synaptic AMPA receptor. Proceedings of the National Academy of Sciences of the United States of America. 101 [PubMed]

Lev-Ram V, Mehta SB, Kleinfeld D, Tsien RY. (2003). Reversing cerebellar long-term depression. Proceedings of the National Academy of Sciences of the United States of America. 100 [PubMed]

Lev-Ram V, Nebyelul Z, Ellisman MH, Huang PL, Tsien RY. (1997). Absence of cerebellar long-term depression in mice lacking neuronal nitric oxide synthase. Learning & memory (Cold Spring Harbor, N.Y.). 4 [PubMed]

Lev-Ram V, Wong ST, Storm DR, Tsien RY. (2002). A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP. Proceedings of the National Academy of Sciences of the United States of America. 99 [PubMed]

Lin LL et al. (1993). cPLA2 is phosphorylated and activated by MAP kinase. Cell. 72 [PubMed]

Linden DJ. (1996). A protein synthesis-dependent late phase of cerebellar long-term depression. Neuron. 17 [PubMed]

Linden DJ. (2012). A late phase of LTD in cultured cerebellar Purkinje cells requires persistent dynamin-mediated endocytosis. Journal of neurophysiology. 107 [PubMed]

Linden DJ, Connor JA. (1991). Participation of postsynaptic PKC in cerebellar long-term depression in culture. Science (New York, N.Y.). 254 [PubMed]

Lipina C, Hundal HS. (2017). The endocannabinoid system: 'NO' longer anonymous in the control of nitrergic signalling? Journal of molecular cell biology. 9 [PubMed]

Lüthi A et al. (1999). Hippocampal LTD expression involves a pool of AMPARs regulated by the NSF-GluR2 interaction. Neuron. 24 [PubMed]

Malinow R, Malenka RC. (2002). AMPA receptor trafficking and synaptic plasticity. Annual review of neuroscience. 25 [PubMed]

Matsuda S, Launey T, Mikawa S, Hirai H. (2000). Disruption of AMPA receptor GluR2 clusters following long-term depression induction in cerebellar Purkinje neurons. The EMBO journal. 19 [PubMed]

Nabavi S et al. (2014). Engineering a memory with LTD and LTP. Nature. 511 [PubMed]

Namiki S, Kakizawa S, Hirose K, Iino M. (2005). NO signalling decodes frequency of neuronal activity and generates synapse-specific plasticity in mouse cerebellum. The Journal of physiology. 566 [PubMed]

Newton M, Niewczas I, Clark J, Bellamy TC. (2010). A real-time fluorescent assay of the purified nitric oxide receptor, guanylyl cyclase. Analytical biochemistry. 402 [PubMed]

Noel J et al. (1999). Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism. Neuron. 23 [PubMed]

O'Flaherty JT, Chadwell BA, Kearns MW, Sergeant S, Daniel LW. (2001). Protein kinases C translocation responses to low concentrations of arachidonic acid. The Journal of biological chemistry. 276 [PubMed]

Piochon C et al. (2016). Calcium threshold shift enables frequency-independent control of plasticity by an instructive signal. Proceedings of the National Academy of Sciences of the United States of America. 113 [PubMed]

Powell K, Mathy A, Duguid I, Häusser M. (2015). Synaptic representation of locomotion in single cerebellar granule cells. eLife. 4 [PubMed]

Safo PK, Regehr WG. (2005). Endocannabinoids control the induction of cerebellar LTD. Neuron. 48 [PubMed]

Sheng M, Lee SH. (2001). AMPA receptor trafficking and the control of synaptic transmission. Cell. 105 [PubMed]

Shinomura T, Asaoka Y, Oka M, Yoshida K, Nishizuka Y. (1991). Synergistic action of diacylglycerol and unsaturated fatty acid for protein kinase C activation: its possible implications. Proceedings of the National Academy of Sciences of the United States of America. 88 [PubMed]

Sossa KG, Beattie JB, Carroll RC. (2007). AMPAR exocytosis through NO modulation of PICK1. Neuropharmacology. 53 [PubMed]

Stamler JS et al. (1992). S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds. Proceedings of the National Academy of Sciences of the United States of America. 89 [PubMed]

Stephens LR et al. (1997). The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell. 89 [PubMed]

Su LD, Wang DJ, Yang D, Shen Y, Hu YH. (2013). Retrograde cPLA2a/arachidonic acid/2-AG signaling is essential for cerebellar depolarization-induced suppression of excitation and long-term potentiation. Cerebellum (London, England). 12 [PubMed]

Sánchez MG, Ruiz-Llorente L, Sánchez AM, Díaz-Laviada I. (2003). Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(2) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction. Cellular signalling. 15 [PubMed]

Tanaka K, Augustine GJ. (2008). A positive feedback signal transduction loop determines timing of cerebellar long-term depression. Neuron. 59 [PubMed]

Tanaka K et al. (2007). Ca2+ requirements for cerebellar long-term synaptic depression: role for a postsynaptic leaky integrator. Neuron. 54 [PubMed]

Tsuruno S, Hirano T. (2007). Persistent activation of protein kinase Calpha is not necessary for expression of cerebellar long-term depression. Molecular and cellular neurosciences. 35 [PubMed]

Tucker DE et al. (2009). Role of phosphorylation and basic residues in the catalytic domain of cytosolic phospholipase A2alpha in regulating interfacial kinetics and binding and cellular function. The Journal of biological chemistry. 284 [PubMed]

Vanhaesebroeck B, Waterfield MD. (1999). Signaling by distinct classes of phosphoinositide 3-kinases. Experimental cell research. 253 [PubMed]

Wang DJ et al. (2014). Long-term potentiation at cerebellar parallel fiber-Purkinje cell synapses requires presynaptic and postsynaptic signaling cascades. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34 [PubMed]

Wang YT, Linden DJ. (2000). Expression of cerebellar long-term depression requires postsynaptic clathrin-mediated endocytosis. Neuron. 25 [PubMed]

Yamaguchi K, Itohara S, Ito M. (2016). Reassessment of long-term depression in cerebellar Purkinje cells in mice carrying mutated GluA2 C terminus. Proceedings of the National Academy of Sciences of the United States of America. 113 [PubMed]

van Woerden GM et al. (2009). betaCaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses. Nature neuroscience. 12 [PubMed]

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