Model demonstrates mechanism whereby two kinetically distinct inward currents act synergistically to prolong subthreshold depolarization. The important currents are a persistent Na current (with fast kinetics) and a persistent Ca current (with slower kinetics). Model also includes a slow K current and transient Ca current, in addition to standard HH currents. Model parameters are set to values used in Fig. 8A. Simulation shows prolonged depolarizations in response to two brief stimuli.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Spinal cord lamina I neuron
Currents: I Na,p; I K,Ca; I Calcium
Model Concept(s): Action Potential Initiation; Nociception; Delay; Calcium dynamics
Simulation Environment: NEURON
Implementer(s): Prescott, Steven [steve.prescott at sickkids.ca]]
References:
Prescott SA, De Koninck Y. (2005). Integration time in a subset of spinal lamina I neurons is lengthened by sodium and calcium currents acting synergistically to prolong subthreshold depolarization. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]