In this review some of the recent work carried out in our laboratory concerning the functional role of GABAergic signalling at immature mossy fibres (MF)-CA3 principal cell synapses has been highlighted. To compare the relative strength of CA3 pyramidal cell output in relation to their MF glutamatergic or GABAergic inputs in postnatal development, a realistic model was constructed taking into account the different biophysical properties of these synapses.
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA3 pyramidal GLU cell
Currents: I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I M; I h; I Calcium
Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Bursting; Temporal Pattern Generation; Active Dendrites; Detailed Neuronal Models; Action Potentials; Synaptic Integration; Spike Frequency Adaptation
Simulation Environment: NEURON
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu]
References:
Safiulina VF et al. (2010). Control of GABA Release at Mossy Fiber-CA3 Connections in the Developing Hippocampus. Frontiers in synaptic neuroscience. 2 [PubMed]