"... In apical dendrites of neocortical pyramidal neurons, calcium spikes are known to contribute to burst generation, but a comparable understanding of basal dendritic mechanisms is lacking. Here we show that NMDA spikes in basal dendrites mediate both detection and generation of bursts through a postsynaptic mechanism. High-frequency inputs to basal dendrites markedly facilitated NMDA spike initiation compared with low-frequency activation or single inputs. ..."
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Neocortex L5/6 pyramidal GLU cell
Receptors: AMPA; NMDA; Glutamate
Model Concept(s): Action Potential Initiation; Bursting; Action Potentials; Synaptic Integration
Simulation Environment: NEURON
Implementer(s): Polsky, Alon [alonpol at tx.technion.ac.il]
References:
Polsky A, Mel B, Schiller J. (2009). Encoding and decoding bursts by NMDA spikes in basal dendrites of layer 5 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]