Multiplication by NMDA receptors in Direction Selective Ganglion cells (Poleg-Polsky & Diamond 2016)

The model demonstrates how signal amplification with NMDARs depends on the synaptic environment. When direction selectivity (DS) detection is mediated by DS inhibition, NMDARs multiply other synaptic conductances. In the case of DS tuned excitation, NMDARs contribute additively.

Model Type: Dendrite; Neuron or other electrically excitable cell; Realistic Network; Synapse

Cell Type(s): Retina ganglion GLU cell

Currents: I K; I Na,t

Receptors: AMPA; NMDA; GabaA; Nicotinic

Transmitters: Glutamate; Acetylcholine; Gaba

Model Concept(s): Direction Selectivity; Synaptic Integration; Vision

Simulation Environment: NEURON

Implementer(s): Polsky, Alon [alonpol at tx.technion.ac.il]

References:

Poleg-Polsky A, Diamond JS. (2016). NMDA Receptors Multiplicatively Scale Visual Signals and Enhance Directional Motion Discrimination in Retinal Ganglion Cells. Neuron. 89 [PubMed]